Current Genetics

, Volume 59, Issue 1–2, pp 1–31 | Cite as

Regulations of sugar transporters: insights from yeast

  • J. HorákEmail author


Transport across the plasma membrane is the first step at which nutrient supply is tightly regulated in response to intracellular needs and often also rapidly changing external environment. In this review, I describe primarily our current understanding of multiple interconnected glucose-sensing systems and signal-transduction pathways that ensure fast and optimum expression of genes encoding hexose transporters in three yeast species, Saccharomyces cerevisiae, Kluyveromyces lactis and Candida albicans. In addition, an overview of GAL- and MAL-specific regulatory networks, controlling galactose and maltose utilization, is provided. Finally, pathways generating signals inducing posttranslational degradation of sugar transporters will be highlighted.


Glucose signalling Sugar transporter Sensing element Yeast 



I am grateful to Jaromir Zahradka for figure design and preparation and to Arnost Kotyk for careful reading the manuscript. This work has been supported by grant GACR P503/10/0307 and RVO:67985823.


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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Membrane Transport, Institute of PhysiologyAcademy of Sciences of the Czech Republic, v.v.i.Prague 4Czech Republic

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