Current Genetics

, Volume 43, Issue 4, pp 245–254

Evolution, biochemistry and genetics of protein kinase C in fungi

Review Article

DOI: 10.1007/s00294-003-0403-6

Cite this article as:
Schmitz, HP. & Heinisch, J.J. Curr Genet (2003) 43: 245. doi:10.1007/s00294-003-0403-6


From yeast to humans, protein kinase C is an enzyme of central importance in signal transduction processes. In baker's yeast, Saccharomyces cerevisiae, a single gene encoding Pkc1p has been identified. Mutant analyses revealed that Pkc1p function is essential to ensure cellular integrity through regulation of a specific MAP kinase cascade. Due to the involvement of different defective mammalian isozymes in various diseases and the model character of simple eukaryotes, increasing attention has been paid to the structure and regulation of the enzymes of fungal origin. This review summarizes the knowledge gathered so far.


Signal transduction MAP kinase Yeast Protein domains Regulation Fungi 

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Biozentrum Basel, Institut für Angewandte MikrobiologieBio-Pharmazentrum University of BaselBaselSwitzerland
  2. 2.Fachbereich Biologie/Chemie, AG GenetikUniversität OsnabrückOsnabrückGermany

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