Der Pathologe

, 30:185

Nierenbeckenkarzinom

Ein anderer Urotheltumor?
Hauptreferate

Zusammenfassung

Die urothelialen Tumoren des Nierenbeckens und des Harnleiters unterscheiden sich in ihrem histopathologischen Phänotyp nicht von denen der Harnblase. Trotzdem ergeben sich bei differenzierter Betrachtung wesentliche tumorbiologische Aspekte: Das Ursprungsgewebe (Urothel) im oberen Harntrakt und in der Harnblase unterscheidet sich in entwicklungsgeschichtlicher Herkunft, morphologischer Differenzierung und physiologischer Funktion. Für die Tumoren des oberen Harntrakts werden spezifische Wege der Tumorpathogenese, z. B. im Rahmen des „Hereditary-nonpolyposis-colorectal-cancer“- (HNPCC-)Syndroms, und der Tumorausbreitung (intraluminale Tumorausbreitung) beschrieben. Klinisch-epidemiologische Befunde weisen auf spezifische Beziehungen zwischen den beiden Tumorlokalisationen hin.

Schlüsselwörter

Urothelkarzinom Harnblase Nierenbecken Urothelfunktion Pathogenese 

Renal pelvic carcinoma

A different urothelial tumor?

Abstract

Urothelial tumors of the renal pelvis and the ureter do not differ from those of the urinary bladder concerning histopathological phenotypes. However, with respect to tumor biology there are relevant differences between the two tumor locations. The originating tissue (urothelium) of the bladder and of the upper urinary tract varies significantly with respect to developmental origin, morphology and physiological function. Specific pathways of tumorigenesis (e.g. hereditary non-polyposis colorectal cancer, HNPCC) and tumor propagation (seeding) are described for tumors of the upper urinary tract. Clinical epidemiological data indicate specific correlations between the two tumor locations.

Keywords

Urothelial carcinoma Urinary bladder Renal pelvis Urothelial function Tumor pathogenesis 

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Copyright information

© Springer Medizin Verlag 2009

Authors and Affiliations

  1. 1.Institut für PathologieUniversität RegensburgRegensburgDeutschland

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