Polymer Bulletin

, Volume 38, Issue 4, pp 387–393

Synthesis of chitosan derivatives with quaternary ammonium salt and their antibacterial activity

  • Chun Ho Kim
  • Jang Won Choi
  • Heung Jae Chun
  • Kyu Suk Choi
Article

Summary

N-alkyl chitosan derivatives were prepared by introducing alkyl groups into the amine groups of chitosan via Schiff’s base intermediates. Quaternization of the N-alkyl chitosan derivatives were carried out using methyl iodide to produce water soluble cationic polyelectrolytes, novel chitosan derivatives with quaternary ammonium salt. Their antibacterial activities against S. aureus were explored by the viable cell counting method in acetate buffer(pH 6.0). The antibacterial activities of the chitosan derivatives with quaternary ammonium salt increased with increase in the chain length of the alkyl substituent, and this increased activity could be ascribed to the contribution of the increased hydrophobic properties of the derivatives.

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Chun Ho Kim
    • 1
  • Jang Won Choi
    • 1
  • Heung Jae Chun
    • 1
  • Kyu Suk Choi
    • 1
  1. 1.Department of Industrial Chemistry, College of EngineeringHanyang UniversitySeoulKorea
  2. 2.Research Institute of Industrial ScienceHanyang UniversitySeoulKorea

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