Alginate derivative-functionalized silica nanoparticles: surface modification and characterization
- 4 Downloads
The bare silica nanoparticles (SiO2 NPs) synthesized by Stöber method is very hydrophilic and chemically inert, which may suffer from particles aggregation and low biocompatibility when they are used in physiological media. For this case, we attempted to conduct surface functionalization of SiO2 NPs by Ugi multicomponent reaction, using amphiphilic amidic alginate derivative (AAD) as the modifier. The successful synthesis of amidic alginate derivative-functionalized silica nanoparticles (AAD-SiO2 NPs) was confirmed by FT-IR spectroscopy, 1H NMR spectrometer, X-ray photoelectron spectroscopy and thermal gravimetric analysis. The covalent bonding of alginate derivative onto the surface of SiO2 NPs increased their average diameter and zeta potential, which effectively improved their colloidal stability in PBS. Additionally, surface tension measurements and cell studies results revealed that the resultant AAD-SiO2 NPs possessed relatively high surface activity and cytocompatibility, which exhibited great potential in the biomedical field.
KeywordsNanoparticles Polymers Ugi reaction Silica Amidic alginate derivative
This work was financially supported by the Natural Science Foundation of Hainan Province (218QN233) and the National Natural Science Foundation of China (21566009).
- 5.Graf C, Gao Q, Schütz I, Noufele CN, Noufele W, Posselt U, Korotianskiy E, Nordmeyer D, Rancan F, Hadam S, Vogt A, Lademann J, Haucke V, Rühl E (2012) Surface functionalization of silica nanoparticles supports colloidal stability in physiological media and facilitates internalization in cells. Langmuir 28:7598–7613CrossRefGoogle Scholar
- 20.Yan H, Chen X, Li J, Feng Y, Wu J, Lin Q, Shi Z, Wang X (2016) Synthesis of amidic alginate derivatives modified silica nanoparticles via Ugi multicomponent reaction. Chem J Chin Univ 37:1018–1024Google Scholar