Polyethylene glycol–gum acacia-based multidrug delivery system for controlled delivery of anticancer drugs
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Breast cancer is a chronic disease that is characterized by an uncontrolled growth of abnormal cells from the breast tissue. It is one of the leading causes of mortality among women worldwide because of its early metastasis, aggressive behavior and resistance to the currently used anticancer drugs. Most of these drugs suffer from poor absorption and toxicity, and lack long-term efficaciousness because of drug resistance. Recently, polymeric thermosensitive hydrogels have emerged as excellent drug delivery systems for anticancer drugs with the potential to improve the overall therapeutic effect of the incorporated drug. In this current research, doxorubicin and curcumin were loaded into biodegradable PEG–gum acacia-based hydrogels. These hydrogels were pH-sensitive, biodegradable and non-toxic. The release mechanism of the drugs from the hydrogels was pH-dependent. In vitro cytotoxicity studies on MCF-7 cancer cell lines further confirmed that the incorporation of doxorubicin and curcumin into the hydrogels resulted in significant cytotoxic effect when compared to the free drugs, suggesting that these hydrogels are potential dual-drug delivery systems. The cytotoxic effect was dose- and time-dependent.
KeywordsBreast cancer Hydrogel Dual-drug delivery systems Curcumin Doxorubicin
The financial supports from the National Research Foundation (NRF), the South Africa Medical Research Council (Self-Initiated Research) (MRC) and the North-West University (NWU), South Africa, toward this research are hereby acknowledged. The views and opinions expressed in this manuscript are those of the authors and not of NWU, MRC or NRF.
Compliance with ethical standards
Conflict of interest
The authors report no conflicts of interest.
- 2.Mondal J, Panigrahi AK, Khuda-Bukhsh AR (2014) Conventional chemotherapy: problems and scope for combined therapies with certain herbal products and dietary supplements. Austin J Mol Cell Biol 1(1):1–10Google Scholar
- 24.Shaikh MM, Lonikar MS, Lonikar SV (2014) Gum acacia-acrylic acid hydrogels: pH sensitive materials for drug delivery system. Asian J Res Chem 7:407–411Google Scholar
- 26.Cao H, Yang Y, Shao ZZ (2015) Doxorubicin hydrochloride and curcumin loaded silk fibroin/hydroxypropylcellulose hydrogels for localized chemotherapy of cancer. J Control Release 213:e8–e152Google Scholar
- 30.Varaprasad K, Vimala K, Ravindra S et al (2011) Development of sodium carboxymethyl cellulose-based poly (acrylamide-co-2acrylamido-2-methyl-1-propane sulfonic acid) hydrogels for in vitro drug release studies of ranitidine hydrochloride an anti-ulcer drug. Polym Plast Technol Eng 50:1199–1207CrossRefGoogle Scholar
- 33.Holowka EP, Sujata KB (2014) Controlled release system. In: Bellomo EG (ed) Drug Delivery: materials design and clinical perspective. Springer, New YorkGoogle Scholar
- 35.Maheshkuma S, Reddy K, Goud P et al (2013) Formulation and characterization of doxorubicin hydrochloride liposomes by double emulsion method. Int Res J Pharm 4:197–201Google Scholar
- 38.Shaikh MM, Lonikar MS, Lonikar SV (2014) Gum acacia-acrylic acid hydrogels: pH sensitive materials for drug delivery system. Asian J Res Chem 7:407–411Google Scholar
- 45.Yin OS, Ahmad I, Amin MC (2015) Synthesis of chemical cross-linked gelatin hydrogel reinforced with cellulose nanocrystals (CNC). In: AIP conference proceedings, Bandung, Indonesia, pp 375–380Google Scholar
- 50.Tan SY, Ang CY, Mahmood A et al (2016) Doxorubicin-loaded metal–organic gels for pH and glutathione dual-responsive release. Chem NanoMat 2:504–508Google Scholar
- 60.Chavis MA, You NH, Maeda R et al (2012) Cleavable self-organized thin films: block copolymers and brushes. Abstracts of Papers of the American Chemical Society, Amer Chem Soc 1155, 16th St, Nw, Washington, DC 20036, USAGoogle Scholar
- 63.Thakur A, Wanchoo R, Singh P (2012) Hydrogels of poly (acrylamide-co-acrylic acid): in vitro study on release of gentamicin sulfate. Chem Biochem Eng Q 25:471–482Google Scholar