A facile method to fabricate an antimicrobial coating based on poly(1-vinyl-3-allylimidazolium iodide) (PAVI) and poly(ethylene glycol) dimethyl acrylate (PEGDMA)

  • Chao ZhouEmail author
  • Hongqin Song
  • Feifei Zhang
  • Jun Liu
  • Jianghua Li
  • Bo Liu
  • Jingshi LiangEmail author
Original Paper


Biomedical device-related infections have been a great concern over the past decades. In this work, cationic macromolecules poly(1-vinyl-3-allylimidazolium iodide) (PAVI) with antibactericidal ability were prepared and grafted on nose clips by surface-initiated polymerization via plasma/autoclaving method. The precursor poly(1-vinylimidazole) was synthesized by surface-initiated polymerization and then quaternarized to form polymeric quaternary ammonia salts which have been commonly used as bactericidal materials. We first synthesized a series of different formulations of cationic PAVI and hydrophilic poly(ethylene glycol) dimethyl acrylate graftings onto nose clips by thermal-initiating polymerization with covalent bonds for antimicrobial surface modification. Antibacterial test results showed that the cationic–hydrophilic coatings exhibited excellent antibacterial behaviors for multidrug-resistant bacteria such as vancomycin-resistant Enterococcus and methicillin-resistant Staphylococcus aureus. The in vitro log reduction value for could reach 6.0 and 8.6, respectively, and the in vivo log reduction value could reach 1.3 and 2.0, respectively. In vitro cytotoxicity indicated that PAVI coatings were non-leachable and exhibited no toxicity toward mammal cells. This rationally designed polycationic antimicrobial coating displayed great potential application in combating implant-associated infections on biomedical devices.

Graphical abstract


Antibacterial property Surface coating Surface-initiated polymerization Log reduction Biomedical materials 



This work was supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). We also thank the fund support by Changsha University of Science and Technology.

Compliance with ethical standards

Conflict of interest

The authors declare that they no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of Materials Science and EngineeringChangsha University of Science and TechnologyChangshaChina
  2. 2.School of Chemical and Biomedical EngineeringNanyang Technological University (NTU)SingaporeSingapore
  3. 3.College of Veterinary MedicineYangzhou UniversityYangzhouChina
  4. 4.Department of Materials Science and EngineeringNational University of SingaporeSingaporeSingapore
  5. 5.Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijingChina

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