A facile method to fabricate an antimicrobial coating based on poly(1-vinyl-3-allylimidazolium iodide) (PAVI) and poly(ethylene glycol) dimethyl acrylate (PEGDMA)
- 47 Downloads
Biomedical device-related infections have been a great concern over the past decades. In this work, cationic macromolecules poly(1-vinyl-3-allylimidazolium iodide) (PAVI) with antibactericidal ability were prepared and grafted on nose clips by surface-initiated polymerization via plasma/autoclaving method. The precursor poly(1-vinylimidazole) was synthesized by surface-initiated polymerization and then quaternarized to form polymeric quaternary ammonia salts which have been commonly used as bactericidal materials. We first synthesized a series of different formulations of cationic PAVI and hydrophilic poly(ethylene glycol) dimethyl acrylate graftings onto nose clips by thermal-initiating polymerization with covalent bonds for antimicrobial surface modification. Antibacterial test results showed that the cationic–hydrophilic coatings exhibited excellent antibacterial behaviors for multidrug-resistant bacteria such as vancomycin-resistant Enterococcus and methicillin-resistant Staphylococcus aureus. The in vitro log reduction value for could reach 6.0 and 8.6, respectively, and the in vivo log reduction value could reach 1.3 and 2.0, respectively. In vitro cytotoxicity indicated that PAVI coatings were non-leachable and exhibited no toxicity toward mammal cells. This rationally designed polycationic antimicrobial coating displayed great potential application in combating implant-associated infections on biomedical devices.
KeywordsAntibacterial property Surface coating Surface-initiated polymerization Log reduction Biomedical materials
This work was supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). We also thank the fund support by Changsha University of Science and Technology.
Compliance with ethical standards
Conflict of interest
The authors declare that they no conflict of interest.
- 1.Grainger DW, van der Mei HC, Jutte PC, van den Dungen J, Schultz MJ, van der Laan B, Zaat SAJ, Busscher HJ (2013) Critical factors in the translation of improved antimicrobial strategies for medical implants and devices. Biomaterials 34(37):9237–9243. https://doi.org/10.1016/j.biomaterials.2013.08.043 CrossRefPubMedGoogle Scholar
- 5.Campoccia D, Montanaro L, Arciola CR (2006) The significance of infection related to orthopedic devices and issues of antibiotic resistance. Biomaterials 27(11):2331–2339. https://doi.org/10.1016/j.biomaterials.2005.11.044 CrossRefPubMedGoogle Scholar
- 8.Harris LG, Tosatti S, Wieland M, Textor M, Richards RG (2004) Staphylococcus aureus adhesion to titanium oxide surfaces coated with non-functionalized and peptide-functionalized poly(l-lysine)-grafted-poly(ethylene glycol) copolymers. Biomaterials 25(18):4135–4148. https://doi.org/10.1016/j.biomaterials.2003.11.033 CrossRefPubMedGoogle Scholar
- 11.Guyomard A, De E, Jouenne T, Malandain JJ, Muller G, Glinel K (2008) Incorporation of a hydrophobic antibacterial peptide into amphiphilic polyelectrolyte multilayers: a bioinspired approach to prepare biocidal thin coatings. Adv Funct Mater 18(5):758–765. https://doi.org/10.1002/adfm.200700793 CrossRefGoogle Scholar
- 13.Pan YF, Xiao HN (2011) Rendering Rayon fibres antimicrobial and thermal-responsive via layer-by-layer self-assembly of functional polymers. In: Cao Z, He YH, Sun L, Cao XQ (eds) Application of chemical engineering. Advanced Materials Research, Pts 1–3, vol 236–238. Trans Tech Publications Ltd, Durnten-Zurich, pp 1103–1106. https://doi.org/10.4028/www.scientific.net/AMR.236-238.1103
- 23.Campoccia D, Montanaro L, Arciola CR (2013) A review of the biomaterials technologies for infection-resistant surfaces. Biomaterials 34(34):8533–8554. https://doi.org/10.1016/j.biomaterials.2013.07.089 CrossRefPubMedGoogle Scholar
- 24.Zoppe JO, Ataman NC, Mocny P, Wang J, Moraes J, Klok HA (2017) Surface-initiated controlled radical polymerization: state-of-the-art, opportunities, and challenges in surface and interface engineering with polymer brushes. Chem Rev 117(5):4667. https://doi.org/10.1021/acs.chemrev.7b00093 CrossRefPubMedGoogle Scholar
- 25.Zhou C, Wu Y, Thappeta KRV, Subramanian JTL, Pranantyo D, Kang ET, Duan HW, Kline K, Chan-Park MB (2017) In vivo anti-biofilm and anti-bacterial non-leachable coating thermally polymerized on cylindrical catheter. ACS Appl Mater Interfaces 9(41):36269–36280. https://doi.org/10.1021/acsami.7b07053 CrossRefPubMedGoogle Scholar
- 27.Gultekinoglu M, Sarisozen YT, Erdogdu C, Sagiroglu M, Aksoy EA, Oh YJ, Hinterdorfer P, Ulubayram K (2015) Designing of dynamic polyethyleneimine (PEI) brushes on polyurethane (PU) ureteral stents to prevent infections. Acta Biomater 21:44–54. https://doi.org/10.1016/j.actbio.2015.03.037 CrossRefPubMedGoogle Scholar