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Polymer Bulletin

, Volume 71, Issue 12, pp 3163–3176 | Cite as

[6]-Gingerol-loaded cellulose acetate electrospun fibers as a topical carrier for controlled release

  • Thanaporn Chantarodsakun
  • Thammasit VongsetskulEmail author
  • Kulachart Jangpatarapongsa
  • Patoomratana Tuchinda
  • Sukanda Uamsiri
  • Chuthamas Bamrungcharoen
  • Supeecha Kumkate
  • Pakorn Opaprakasit
  • Pramuan Tangboriboonrat
Original Paper

Abstract

[6]-Gingerol (6 % w/v)-loaded cellulose acetate (12 % w/v CA; MW ~ 3 × 104 g/mol) fibers (375 ± 107 nm) were prepared by electrospinning at 7.5 kV. ATR-FTIR spectra indicated that the mixture was miscible at this composition. Differential scanning calorimetry revealed that [6]-gingerol was uniformly dispersed in the CA matrix and interrupted the hydrogen bond formation among the CA chains. Controlled release study showed that ~97 % of the loaded [6]-gingerol could be released from the loaded fibers to the acetate buffer solution at 37 °C, whereas only ~74 % of it could be done from the corresponding films. About 92 % of [6]-gingerol in the fibers was dramatically released within 4 h. Release was mainly governed by a diffusion-controlled mechanism. The radical scavenging assay showed antioxidant activity of the loaded fibers. The in vitro cytotoxicity test revealed that the viability of L-929 mouse fibroblast cells to the loaded fibers was ~65 %.

Keywords

Cellulose acetate Controlled release Electrospinning [6]-Gingerol Ultrafine fiber 

Notes

Acknowledgments

Research grants from The Thailand Research Fund (TRF)/Mahidol University (TRG5680070); Thailand Ministry of Science and Technology; Faculty of Science, Mahidol University to T.V.; and from TRF/Commission on Higher Education to P.T. (RTA5480007) are gratefully acknowledged.

Supplementary material

289_2014_1243_MOESM1_ESM.doc (58 kb)
Supplementary material 1 (DOC 57 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Thanaporn Chantarodsakun
    • 1
  • Thammasit Vongsetskul
    • 1
    Email author
  • Kulachart Jangpatarapongsa
    • 2
  • Patoomratana Tuchinda
    • 1
  • Sukanda Uamsiri
    • 1
  • Chuthamas Bamrungcharoen
    • 1
  • Supeecha Kumkate
    • 3
  • Pakorn Opaprakasit
    • 4
  • Pramuan Tangboriboonrat
    • 1
  1. 1.Department of Chemistry, Faculty of ScienceMahidol UniversityBangkokThailand
  2. 2.Center for Innovation Development and Technology Transfer, Department of Clinical Microbiology and Applied Technology, Faculty of Medical TechnologyMahidol UniversityNakhonprathomThailand
  3. 3.Department of Biology, Faculty of ScienceMahidol UniversityBangkokThailand
  4. 4.School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT)Thammasat UniversityPathum ThaniThailand

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