-Gingerol-loaded cellulose acetate electrospun fibers as a topical carrier for controlled release
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-Gingerol (6 % w/v)-loaded cellulose acetate (12 % w/v CA; MW ~ 3 × 104 g/mol) fibers (375 ± 107 nm) were prepared by electrospinning at 7.5 kV. ATR-FTIR spectra indicated that the mixture was miscible at this composition. Differential scanning calorimetry revealed that -gingerol was uniformly dispersed in the CA matrix and interrupted the hydrogen bond formation among the CA chains. Controlled release study showed that ~97 % of the loaded -gingerol could be released from the loaded fibers to the acetate buffer solution at 37 °C, whereas only ~74 % of it could be done from the corresponding films. About 92 % of -gingerol in the fibers was dramatically released within 4 h. Release was mainly governed by a diffusion-controlled mechanism. The radical scavenging assay showed antioxidant activity of the loaded fibers. The in vitro cytotoxicity test revealed that the viability of L-929 mouse fibroblast cells to the loaded fibers was ~65 %.
KeywordsCellulose acetate Controlled release Electrospinning -Gingerol Ultrafine fiber
Research grants from The Thailand Research Fund (TRF)/Mahidol University (TRG5680070); Thailand Ministry of Science and Technology; Faculty of Science, Mahidol University to T.V.; and from TRF/Commission on Higher Education to P.T. (RTA5480007) are gratefully acknowledged.
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