Polymer Bulletin

, Volume 66, Issue 8, pp 1125–1136 | Cite as

Preparation of superparamagnetic β-cyclodextrin-functionalized composite nanoparticles with core–shell structures

  • Ruixue Li
  • Shumei Liu
  • Jianqing Zhao
  • Hideyuki Otsuka
  • Atsushi Takahara
Original Paper

Abstract

In this article, we report an original and feasible protocol for the preparation of superparamagnetic β-cyclodextrin-functionalized composite nanoparticles with core–shell structures via cross linking reaction on the surface of carboxymethyl β-cyclodextrin-modified magnetite (Fe3O4) nanoparticles by using epichlorohydrin as a crosslinking agent. The structure and morphology of the prepared composite nanoparticles were studied by Fourier transform infrared spectrometry, X-ray diffraction measurement, transmission electron microscopy and the thermogravimetric analysis. The results show that the prepared roughly spherical composite nanoparticles (diameter about 10–20 nm) with core–shell structures turned out to be magnetite nanoparticles surface-surrounded by a layer of cross-linked CM-β-cyclodextrin polymer. Results of vibrating sample magnetometry testing and inclusive behaviour studying confirmed the superparamagnetism with saturation magnetization value of 52.0 emu/g in an external applied magnetic field of 20000 Oe and inclusion functionality of the composite nanoparticles consisting of magnetite cores and β-cyclodextrin moiety, which implies very important applications in targeting drug delivery technology and separation for specific substances.

Keywords

β-Cyclodextrin Magnetite (Fe3O4) nanoparticles Composite nanoparticles 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Ruixue Li
    • 1
  • Shumei Liu
    • 1
  • Jianqing Zhao
    • 1
  • Hideyuki Otsuka
    • 2
  • Atsushi Takahara
    • 2
  1. 1.College of Materials Science and EngineeringSouth China University of TechnologyGuangzhou510640China
  2. 2.Institute for Materials Chemistry and EngineeringKyushu UniversityFukuokaJapan

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