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Journal of Mathematical Biology

, Volume 73, Issue 2, pp 469–490 | Cite as

Pulsations with reflected boundary waves: a hydrodynamic reverse transport mechanism for perivascular drainage in the brain

  • M. Coloma
  • J. D. Schaffer
  • R. O. Carare
  • P. R. Chiarot
  • P. HuangEmail author
Article

Abstract

Beta-amyloid accumulation within arterial walls in cerebral amyloid angiopathy is associated with the onset of Alzheimer’s disease. However, the mechanism of beta-amyloid clearance along peri-arterial pathways in the brain is not well understood. In this study, we investigate a transport mechanism in the arterial basement membrane consisting of forward-propagating waves and their reflections. The arterial basement membrane is modeled as a periodically deforming annulus filled with an incompressible single-phase Newtonian fluid. A reverse flow, which has been suggested in literature as a beta-amyloid clearance pathway, can be induced by the motion of reflected boundary waves along the annular walls. The wave amplitude and the volume of the annular region govern the flow magnitude and may have important implications for an aging brain. Magnitudes of transport obtained from control volume analysis and numerical solutions of the Navier–Stokes equations are presented.

Keywords

Perivascular transport Interstitial fluid flow Alzheimer’s disease 

Mathematics Subject Classification

Primary: 76Z05 Physiological Flows 

Notes

Acknowledgments

M.C. would like to acknowledge the support of the Clifford D. Clark Diversity Fellowship. J.D.S., P.R.C., and P.H. would like to acknowledge the State Univeristy of New York at Binghamton University Interdisciplinary Collaborative Grant program for supporting this work.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • M. Coloma
    • 1
  • J. D. Schaffer
    • 2
  • R. O. Carare
    • 3
  • P. R. Chiarot
    • 1
  • P. Huang
    • 1
    Email author
  1. 1.Department of Mechanical EngineeringState University of New York at BinghamtonBinghamtonUSA
  2. 2.College of Community and Public AffairsState University of New York at BinghamtonBinghamtonUSA
  3. 3.Faculty of MedicineUniversity of SouthamptonSouthamptonUK

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