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Journal of Mathematical Biology

, Volume 63, Issue 4, pp 637–662 | Cite as

An externally modulated, noise-driven switch for the regulation of SPI1 in Salmonella enterica serovar Typhimurium

  • Marc Bailly-Bechet
  • Arndt Benecke
  • Wolf Dietrich Hardt
  • Valentina Lanza
  • Alexander Sturm
  • Riccardo Zecchina
Article

Abstract

In this work we consider the regulation system present on the SPI1 pathogenicity island of Salmonella enterica serovar Typhimurium. It is well-known that HilA is the central regulator in the overall scheme of SPI1 regulation and directly binds to virulence operons and activates their expression. The regulation of the expression of HilA is via a complex feed-forward loop involving three transcriptional activators: HilC, HilD and RtsA, and the negative regulator HilE. Our aim is to model this regulation network and study its dynamical behavior. We show that this regulatory system can display a bistable behavior relevant to the biology of Salmonella, and that noise can be a driving force in this system.

Keywords

Salmonella Pathogenicity Regulatory network Bistability Noise 

Mathematics Subject Classification (2000)

92B05 37G10 34D20 34F05 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Marc Bailly-Bechet
    • 1
  • Arndt Benecke
    • 2
  • Wolf Dietrich Hardt
    • 3
  • Valentina Lanza
    • 4
  • Alexander Sturm
    • 3
  • Riccardo Zecchina
    • 5
  1. 1.CNRS UMR 5558, Laboratoire de Biométrie et Biologie EvolutiveUniversité Lyon 1VilleurbanneFrance
  2. 2.CNRS USR 3078Institut des Hautes Études ScientifiquesBures-sur-YvetteFrance
  3. 3.Institute of MicrobiologyETH ZürichZürichSwitzerland
  4. 4.Department of PhysicsPolitecnico di TorinoTorinoItaly
  5. 5.Department of Physics, Politecnico di TorinoHuman Genetics Foundation TorinoTorinoItaly

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