Current Microbiology

, Volume 38, Issue 2, pp 80–85

The Integration Host Factor (IHF) Affects the Expression of the Phosphate-Binding Protein and of Alkaline Phosphatase in Escherichia coli

  • Beny  Spira
  • Ezra  Yagil

DOI: 10.1007/s002849900407

Cite this article as:
Spira, B. & Yagil, E. Curr Microbiol (1999) 38: 80. doi:10.1007/s002849900407

Abstract.

The genes encoding alkaline phosphatase (phoA) and the inducible inorganic phosphate transport system Pst (pstS,C,A,B,U) belong to the PHO regulon. Mutants of Escherichia coli lacking the global regulatory protein integration host factor (IHF) show an increased level of alkaline phosphatase and a decreased level of Pst. IHF binds weakly but specifically to a DNA fragment containing the promoter region of the pst operon but does not bind to a fragment that includes the promoter region of phoA. It is proposed that IHF is a positive regulator of the pst operon and as such controls indirectly the expression of phoA.

Copyright information

© Springer-Verlag New York Inc. 1999

Authors and Affiliations

  • Beny  Spira
    • 1
  • Ezra  Yagil
    • 1
  1. 1.Department of Biochemistry, Tel-Aviv University, Tel-Aviv 69978, Israel IL

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