Current Microbiology

, 33:270 | Cite as

Cooperative interaction between Cra and Fnr in the regulation of the cydAB operon of Escherichia coli

  • Tom M. Ramseier
  • Sharon Y. Chien
  • Milton H. Saier


In vivo and in vitro experiments are reported demonstrating that the catabolite repressoractivator (Cra) protein (formerly designated FruR) regulates expression of the cydAB operon of Escherichia coli encoding cytochrome d oxidase. The Fnr protein is required for Cra-mediated transcriptional control, but the ArcA protein antagonizes the response to Cra. The results establish that Fnr, ArcA, and Cra exert their effects in an interdependent fashion.

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Tom M. Ramseier
    • 1
  • Sharon Y. Chien
    • 1
  • Milton H. Saier
    • 1
  1. 1.Department of BiologyUniversity of California at San DiegoLa JollaUSA

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