Current Microbiology

, Volume 42, Issue 1, pp 39–44 | Cite as

Lactobacillus acidophilus Autolysins Inhibit Helicobacter pylori In Vitro

  • Graciela L. Lorca
  • Torkel Wadström
  • Graciela Font de Valdez
  • Åsa Ljungh

Abstract

Antibacterial activity of 17 strains of lactobacilli was tested against 10 strains of H. pylori. The inhibition observed was related to the acid production and the low pH attained. No relationship between CagA phenotype of H. pylori strains and tolerance to lactic acid was observed. In mixed cultures, L. acidophilus CRL 639 showed an autolytic behavior after 24 h of culture. At this moment, H. pylori CCUG17874 showed a decrease of 2 log-cycle, and no viable count was detected after 48 h. The bactericidal effect of L. acidophilus CRL 639 in mixed cultures is related to a proteinaceous compound released after cell lysis.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag New York Inc. 2001

Authors and Affiliations

  • Graciela L. Lorca
    • 1
  • Torkel Wadström
    • 2
  • Graciela Font de Valdez
    • 1
  • Åsa Ljungh
    • 2
  1. 1.Centro de Referencia para Lactobacilos (CERELA), Chacabuco 145, 4000 Tucumán, ArgentinaAR
  2. 2.Department of Medical Microbiology and Infectious Diseases, University of Lund, Sölvegatan 23, S-223 62 Lund, SwedenSE

Personalised recommendations