Aspergillus galactomannan detection: Trichoderma as a cause of positive results
Aspergillus galactomannan immunoassay is a main diagnostic and monitoring tool in medical mycology. However, the specificity of the method can be skewered by the presence of several other fungi. Trying to diagnose a possible fungal infection of the lower respiratory tract in a haematology patient, it appeared that the fungus Trichoderma longibrachiatum is an additional probable cause of positive galactomannan results. Although, that Trichoderma is a rare but emerging pathogen in immunocompromised patients, the above information could be a caution point in the clinical evaluation of diagnostic results.
AMM and KS prepared the solutions, performed several parts of the methodology and searched the references. EZ performed a big part of the technical work of the methodology. EY treated the patient, prepared the clinical data and revised the text. TAV being responsible of the Mycology Lab conceived and designed the study, wrote and revised the paper and performed a part of the methodology.
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 7.De Pauw B, Walsh TJ, Donnelly JP et al (2008) Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis 46:1813–1821CrossRefGoogle Scholar
- 10.Food and Drug Administration (2015–2016) Galactomannan. http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm472606.pdf
- 14.Boch T, Reinwald M, Spiess B et al (2018) Detection of invasive pulmonary aspergillosis in critically ill patients by combined use of conventional culture, galactomannan, 1-3-beta-D-glucan and Aspergillus specific nested polymerase chain reaction in a prospective pilot study. J Crit Care 47:198–203CrossRefGoogle Scholar