Current Microbiology

, Volume 74, Issue 5, pp 623–631 | Cite as

Selection of Cholesterol-Lowering Lactic Acid Bacteria and its Effects on Rats Fed with High-Cholesterol Diet

  • Yufang Liu
  • Fengchun Zhao
  • Jiye Liu
  • Huimin Wang
  • Xiao Han
  • Yongxin Zhang
  • Zhengyou Yang


High cholesterol level in serum is a major factor of influence for coronary heart disease. The cholesterol-lowering ability of lactic acid bacteria (LAB) without side effects makes them more and more attractive. Seventy-nine strains of LAB isolated from fermented food were screened in vitro for their ability to assimilate cholesterol. Then, ten strains which exhibited higher ability of cholesterol assimilation were investigated with the characteristics of acidic resistance, bile salt tolerance, and cell adhesion. According to the results, the best strain LP96 was picked out, and used to evaluate its effects on the high-cholesterol diet-fed rats. The results demonstrated that the levels of serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol, and liver TC and TG were reduced significantly in the groups that received the strain LP96 solution compared with the model group, and that the serum high-density lipoprotein cholesterol levels were increased without any significant difference. Furthermore, LP96 also showed good antioxidative activity and improvement of intestinal microbial balance in the rats. Thus, LP96 may be a promising probiotics with potential cholesterol-lowering ability.


Lactic Acid Bacterium Bile Salt Model Group Lactic Acid Bacterium Strain Liver Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the National Natural Science Foundation of China (grant numbers 30972050, 31271873).

Compliance with Ethical Standards

Conflict of interest

The authors declare that there are no conflicts of interest with any financial organization.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Yufang Liu
    • 1
  • Fengchun Zhao
    • 1
  • Jiye Liu
    • 1
  • Huimin Wang
    • 1
  • Xiao Han
    • 1
  • Yongxin Zhang
    • 1
  • Zhengyou Yang
    • 1
  1. 1.Key Laboratory for Agricultural Microbiology, Department of Microbiology College of Life ScienceShandong Agricultural UniversityTaianChina

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