Impact of Probiotic SYNBIO® Administered by Vaginal Suppositories in Promoting Vaginal Health of Apparently Healthy Women
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The purpose of this study was to investigate whether vaginal administration of probiotic Lactobacillus results in their colonization and persistence in the vagina and whether it promotes normalization and maintenance of pH and Nugent score. A single-arm, open-label controlled towards the baseline (pre–post) study including 35 apparently healthy women was conducted. Each woman was examined three times during the study. Women were instructed to receive daily for 7 days, the probiotic suppositories SYNBIO® gin (Lactobacillus rhamnosus IMC 501® and Lactobacillus paracasei IMC 502®). Vaginal swabs were collected during visit 1, 2, and 3 to determine the total lactobacilli count, the presence of the two administered bacteria, the measure of the pH, and the estimation of Nugent score. Evaluation of treatment tolerability was based on analysis of the type and occurrence of adverse events. The probiotic vaginal suppository was well tolerated and no side effects were reported. Intermediate Nugent score was registered in 40 % of women at visit 1 and these intermediate scores reverted to normal at day 7 (end of treatment) in 20 % of subjects. Administration of SYNBIO® gin contributed to a significant increase in the lactobacilli level at visit 2. Molecular typing revealed the presence of the two strains originating from SYNBIO® gin in 100 % of women at visit 2 and 34 % at visit 3. No significant changes were registered for pH between visits. The SYNBIO® gin product is safe for daily use in healthy women and it could be useful to restore and maintain a normal vaginal microbiota.
KeywordsLactobacillus Bacterial Vaginosis Vaginal Swab Vaginal Epithelium Vaginal Microbiota
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
Informed consent was obtained from all individuals participants included in the study.
- 18.Parent D, Bossens M, Bayot D, Kirkpatrick C, Graf F, Wilkinson FE et al (1996) In vitro evaluation on HeLa cells of protective mechanisms of probiotic lactobacilli against Candida clinical isolates. Arzneim.Forsschung 46:68–73Google Scholar
- 27.Verdenelli MC (2007) Assessment of Novel Probiotic Lactobacillus Strains from human feces for the production of functional foods. dissertation, University of CamerinoGoogle Scholar
- 33.Young JP, Downer HL, Eardly BD (1991) Phylogeny of the phototrophic Rhizobium strain BTAi1 by polymerase chain reaction-based sequencing of a 16S rRNA gene segment. J Bacteriol 173:271–277Google Scholar