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Current Microbiology

, Volume 68, Issue 2, pp 204–210 | Cite as

Bactericidal Genes of Staphylococcal Bacteriophage Sb-1

  • Ekaterine Tevdoradze
  • Leila Kvachadze
  • Mzia KutateladzeEmail author
  • Charles R. StewartEmail author
Article

Abstract

Bacteriophage genes offer a potential resource for development of new antibiotics. Here, we identify at least six genes of Staphylococcus aureus phage Sb-1 that have bactericidal activity when expressed in Escherichia coli. Since the natural host is gram-positive, and E. coli is gram-negative, it is likely that a variety of quite different bacterial pathogens would be susceptible to each of these bactericidal activities, which therefore might serve as the basis for development of new wide-spectrum antibiotics. We show that two of these gene products target E. coli protein synthesis.

Keywords

Bactericidal Activity Early Promoter BglII Site Lytic Bacteriophage Cytotoxic Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was performed with support of the DHHS Biotechnology Engagement Program (BTEP 20/ISTC G-595 project).

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Laboratory of Molecular BiologyG. Eliava Institute of Bacteriophages, Microbiology and VirologyTbilisiGeorgia
  2. 2.Department of Biochemistry and Cell BiologyRice UniversityHoustonUSA
  3. 3.Department of Arts and SciencesIlia State UniversityTbilisiGeorgia

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