Current Microbiology

, 63:484 | Cite as

Probiotic Therapy: Immunomodulating Approach Toward Urinary Tract Infection

  • Sarika Amdekar
  • Vinod SinghEmail author
  • Desh Deepak Singh


Urinary tract infection (UTI) is an extremely common health problem, with an unpredictable history. Members of enterobacteriaceae family such as Escherichia coli, which are normal inhabitants of human intestines, account for the majority of these uncomplicated infections. Rarely, UTI can result from virus or fungus. There is a close correlation between loss of the normal genital microbiota, particularly Lactobacillus species, and an increased incidence of genital and bladder infections. Although antimicrobial agents are generally effective in eradicating these infections, there is a high incidence of recurrence. Use of Lactobacillus species to combat UTI is now giving modern concept of modern genitourinary vaccine with the facts that it not only maintains low pH of the genital area, produces hydrogen peroxide and hinders the growth of E. coli but also activates Toll-like receptor-2 (TLR2), which produces interleukin-10 (IL-10) and myeloid differentiation factor 88 (MyD88). E. coli activates TLR4, which is responsible for the activation of IL-12, extracellular signal–regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). This process downregulates inflammatory reactions caused due to pathogens. Current review covers the probiotics-based TLR therapy and shed some knowledge for the use of Lactobacillus species as probiotics.


Urinary Tract Infection Lactobacillus Innate Immune System Familial Mediterranean Fever Lactobacillus Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

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Supplementary material 1 (DOC 39 kb)


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Sarika Amdekar
    • 1
  • Vinod Singh
    • 1
    Email author
  • Desh Deepak Singh
    • 2
  1. 1.Department of MicrobiologyBarkatullah UniversityBhopalIndia
  2. 2.Department of VirologyCSJM Medical UniversityLukhnowIndia

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