Current Microbiology

, Volume 62, Issue 1, pp 167–172 | Cite as

Quorum Sensing in Aeromonas Species Isolated from Patients in Malaysia

  • Kok-Gan ChanEmail author
  • Savithri D. Puthucheary
  • Xin-Yue Chan
  • Wai-Fong Yin
  • Cheng-Siang Wong
  • Wah-Seng See Too
  • Kek-Heng Chua


Bacterial quorum sensing signal molecules called N-acylhomoserine lactone (AHL) controls the expression of virulence determinants in many Gram-negative bacteria. We determined AHL production in 22 Aeromonas strains isolated from various infected sites from patients (bile, blood, peritoneal fluid, pus, stool and urine). All isolates produced the two principal AHLs, N-butanoylhomoserine lactone (C4-HSL) and N-hexanoyl homoserine lactone (C6-HSL). Ten isolates also produced additional AHLs. This report is the first documentation of Aeromonas sobria producing C6-HSL and two additional AHLs with N-acyl side chain longer than C6. Our data provides a better understanding of the mechanism(s) of this environmental bacterium emerging as a human pathogen.


Quorum Sense Aeromonas Thin Layer Chromatography Plate Violacein Aeromonas Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the Malaysia Ministry of Science, Technology and Innovation under the Science Fund (02-01-03-SF0494) to KGC; and two grants from the University of Malaya namely PJP (Vot F) Research Grant (FS260/2008C) to CSW, and Research University Grant (RG003/09BIO) to KGC, which are all gratefully acknowledged.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Kok-Gan Chan
    • 1
    Email author
  • Savithri D. Puthucheary
    • 2
  • Xin-Yue Chan
    • 1
  • Wai-Fong Yin
    • 1
  • Cheng-Siang Wong
    • 1
  • Wah-Seng See Too
    • 1
  • Kek-Heng Chua
    • 3
  1. 1.Institute of Biological Sciences (Division of Genetics and Molecular Biology), Faculty of ScienceUniversity of MalayaKuala LumpurMalaysia
  2. 2.Department of Medical MicrobiologyUniversity of MalayaKuala LumpurMalaysia
  3. 3.Department of Molecular Medicine, Faculty of MedicineUniversity of MalayaKuala LumpurMalaysia

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