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Hematology and Cell Therapy

, Volume 39, Issue 5, pp 261–264 | Cite as

Immune reconstitution after blood cell transplantation

  • A. Charbonnier
  • D. Sainty
  • C. Faucher
  • C. Arnoulet
  • C. Chabannon
  • D. Blaise
7th Cell Therapy Workshop AMGEN-ROCHE

Abstract

Immune clinical events and pattern of recovery of total lymphocytes, T cells and CD4+/CD8+ T cell subsets, B cells and NK cells, were analysed after allogeneic blood cell transplantation (BCT) for 12 months following transplant (n = 33). Results were compared with immune recovery after allogeneic bone marrow transplantation (BMT) (n = 15) and autologous blood cell transplantation (n = 19). Rates of acute GVHD were comparable in the two allotransplantation groups. Fourteen out of 17 evaluable alloBCT group patients have presented an extensive cGVHD. Total T cell, CD4+T cells and CD56+NK cell reconstitution were improved in alloBCT group vs alloBMT group. CD4+/CD8+ ratio evolution were improved in alloBCT group vs alloBMT and autoBCT groups. These results confirm that rapid immune recovery is associated with allogeneic blood stem cell transplantation.

Key words

Blood cell Transplantation Immune Recovery Allogeneic Transplantation. 

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Copyright information

© Springer-Verlag France 1997

Authors and Affiliations

  • A. Charbonnier
    • 1
  • D. Sainty
    • 2
  • C. Faucher
    • 1
  • C. Arnoulet
    • 2
  • C. Chabannon
    • 1
  • D. Blaise
    • 1
  1. 1.Unité de Transplantation MédullaireInstitut Paoli Calmettes, 232MarseilleFrance
  2. 2.Laboratoire d’HématologieInstitut Paoli Calmettes, 232MarseilleFrance

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