Fibroblast heterogeneity in physiological conditions and fibrotic disease
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Idiopathic Pulmonary Fibrosis Scleroderma Systemic Sclerosis Collagen Synthesis Human Dermal Fibroblast
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- 1.Baragi VM, Brott DA, Qiu L, Conroy MC, Lalwani ND (1995) Immunofluorescence quantitation of stromelysin in human synovial fibroblasts by confocal laser scanning microscopy. Lab Invest 72:484PubMedGoogle Scholar
- 2.Bayreuther K, Rodemann HP, Hommel R, Dittmann K, Albiez M, Francz PI (1988) Human skin fibroblasts in vitro differentiate along a terminal cell lineage. Proc Natl Acad Sci USA 85:5112PubMedCrossRefGoogle Scholar
- 3.Bordin S, Page RC, Narayanan AS (1984) Heterogeneity of normal human diploid fibroblasts: isolation and characterization of one phenotype. Science 223:171PubMedCrossRefGoogle Scholar
- 4.Botstein GR, Sherer GK, Leroy EC (1982) Fibroblast selection in scleroderma. An alternative model of fibrosis. Arthritis Rheum 25:189PubMedCrossRefGoogle Scholar
- 5.Brinckerhoff CE, Nagel JE (1981) Collagenase production by cloned populations of rabbit synovial fibroblasts. Coll Rel Res 5:433Google Scholar
- 6.Byron KL, Villereal ML (1989) Mitogen-induced Ca2+ changes in individual human fibroblasts. Image analysis reveals asynchronous responses which are characteristic for different mitogens. J Biol Chem 264:18234PubMedGoogle Scholar
- 7.Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G (1993) Transforming growth factor-β1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 122:103PubMedCrossRefGoogle Scholar
- 8.Desmouliere A, Redard M, Darby I, Gabbiani G (1995) Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 146:56PubMedGoogle Scholar
- 9.Desmouliere A, Rubbia-Brandt L, Abdm A, Walz T, Macieira-Coelho A, Gabbiani G (1992) α-Smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by γ-interferon. Exp Cell Res 201:64PubMedCrossRefGoogle Scholar
- 10.Ehrlich HP, Desmouliere A, Diegelmann RF, Cohen IK, Compton CC, Garner WL, Kapanci Y, Gabbiani G (1994) Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol 145:105PubMedGoogle Scholar
- 11.Elias JA, Rossman MD, Phillips PD (1987) Phenotypic variability among density-fractionated human lung fibroblasts. Am Rev Respir Dis 135:57PubMedGoogle Scholar
- 12.Essawy M, Soylemezoglu O, Muchaneta-Kubara EC, Shortland J, Brown CB, el Nahas AM (1997) Myofibroblasts and the progression of diabetic nephropathy. Nephrol Dial Transplant 12:43PubMedCrossRefGoogle Scholar
- 13.Falanga V, Kirsner RS (1993) Low oxygen stimulates proliferation of fibroblasts seeded as single cells. J Cell Physiol 154:506PubMedCrossRefGoogle Scholar
- 14.Falanga V, Martin TA, Takagi H, Kirsner RS, Hellman T, Pardes J, Ochoa MS (1993) Low oxygen tension increases mRNA levels of αl (I) procollagen in human dermal fibroblasts. J Cell Physiol 157:408PubMedCrossRefGoogle Scholar
- 15.Falanga V, Qian SW, Danielpour D, Katz MH, Roberts AB, Sporn MB (1991) Hypoxia upregulates the synthesis of TGF-β1 by human dermal fibroblasts. J Invest Dermatol 97:634PubMedCrossRefGoogle Scholar
- 16.Feghali CA, Boulware DW Ferriss JA, Levy LS (1993) Expression of c-myc, c-myb, and c-sis in fibroblasts from affected and unaffected skin of patients with systemic sclerosis. Autoimmunity 16:167PubMedCrossRefGoogle Scholar
- 17.Gabriella A, Di Loreto C, Taborro R, Candela M, Sambo P, Nitti C, Danieli MG, DeLustro F, Dasch JR, Danieli G (1993) Immunohistochemical localization of intracellular and extracellular associated TGF-β in the skin of patients with systemic sclerosis (scleroderma) and primary Raynaud's phenomenon. Clan Immunol Immunopathol 68:340CrossRefGoogle Scholar
- 18.Goldring SR, Stephenson ML, Downie E, Krane SM, Korn JH (1990) Heterogeneity in hormone responses and patterns of collagen synthesis in cloned dermal fibroblasts. J Clin Invest 85:798PubMedCrossRefGoogle Scholar
- 19.Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature 379:88PubMedCrossRefGoogle Scholar
- 20.Higley H, Persichitte K, Chu S, Waegell W, Vancheeswaran R, Black C (1994) Immunocytochemical localization and serologic detection of transforming growth factor-β1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud's phenomenon. Arthritis Rheum 37:278PubMedCrossRefGoogle Scholar
- 21.Jelaska A, Arakawa M, Broketa G, Korn JH (1996) Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts. Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts. Arthritis Rheum 39:1338PubMedCrossRefGoogle Scholar
- 22.Jelaska A, Korn JH (1998) Anti-Fas induces apoptosis and proliferation in human dermal fibroblasts: differences between foreskin and adult fibroblasts. J Cell Physiol 175:19PubMedCrossRefGoogle Scholar
- 23.Jimenez SA, Feldman G, Bashey RI, Bienkowski R, Rosenbloom J (1986) Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts. Biochem 1237:837Google Scholar
- 24.Jordana M, Schulman J, McSharry C, Irving LB, Newhouse MT, Jordana G, Gauldie J (1988) Heterogeneous proliferative characteristics of human adult lung fibroblast lines and clonally derived fibroblasts from control and fibrotic tissue. Am Rev Respir Dis 137:579PubMedGoogle Scholar
- 25.Kahari V-M, Sandberg M, Kalimo H, Vuorio T, Vuorio E (1988) Identification of fibroblasts responsible for increased collagen production in localized scleroderma by in situ hybridization. J Invest Dermatol 90:664PubMedCrossRefGoogle Scholar
- 26.Kawakami T, Ihn H, Xu W, Smith E, LeRoy C, Trojanowska M (1998) Increased expression of TGF-β receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-β signaling to scleroderma phenotype. J Invest Dermatol 110:47PubMedCrossRefGoogle Scholar
- 27.Kirk TZ, Mark ME, Chua CC, Chua BH, Mayes MD (1995) Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TIMP-1. J Biol Chem 270:3423PubMedCrossRefGoogle Scholar
- 28.Korn JH (1983) Fibroblast prostaglandin E2 synthesis. Persistence of an abnormal phenotype after short-term exposure to mononuclear cell products. J Clin Invest 71:1240PubMedCrossRefGoogle Scholar
- 29.Korn JH (1985) Substrain heterogeneity in prostaglandin E2 synthesis of human dermal fibroblasts. Differences in prostaglandin E2 synthetic capacity of substrains are not stimulus-restricted. Arthritis Rheum 28:315PubMedCrossRefGoogle Scholar
- 30.Korn JH, Brinckerhoff CE, Edwards RL (1985) Synthesis of PGE2, collagenase and tissue factor by fibroblast substrains: substrains are differentially activated for different metabolic products. Coll Rel Res 5:437Google Scholar
- 31.Korn JH, Downie E (1989) Clonal interactions in fibroblast proliferation: recognition of self vs. nonself. J Cell Physiol 141:437PubMedCrossRefGoogle Scholar
- 32.Korn JH, Halushka PV, LeRoy EC (1980) Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production. J Clin Invest 65:543PubMedCrossRefGoogle Scholar
- 33.Korn JH, Thrall RS, Wilbur DC, Kream BE, Piela-Smith TH (1992) Fibroblast heterogeneity: clonal selection of fibroblasts as a model for fibrotic disease. In: Phipps RP (ed) Pulmonary fibroblast heterogeneity. CRC Press, Boca Raton, p 119–133Google Scholar
- 34.Korn JH, Torres D, Downie E (1984) Clonal heterogeneity in the fibroblast response to mononuclear cell derived mediators. Annu Rev Cell Biol 27:174Google Scholar
- 35.Kulozik M, Hogg A, Lankat-Buttgereit B, Krieg T (1990) Co-localization of transforming growth factor-β2 with al (I) procollagen mRNA in tissue sections of patients with systemic sclerosis. J Clin Invest 86:917PubMedCrossRefGoogle Scholar
- 36.LeRoy EC (1974) Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast. J Clin Invest 54:880PubMedCrossRefGoogle Scholar
- 37.McDonald JA, Broekelmann TJ, Matheke ML, Crouch E, Koo M, Kuhn CD (1986) A monoclonal antibody to the carboxy-terminal domain of procollagen type I visualizes collagen-synthesizing fibroblasts. Detection of an altered fibroblast phenotype in lungs of patients with pulmonary fibrosis. J Clin Invest 78:1237PubMedCrossRefGoogle Scholar
- 38.Mitsui Y, Schneider EL (1976) Characterization of fractionated human diploid fibroblast cell populations. Exp Cell Res 103:23PubMedCrossRefGoogle Scholar
- 39.Moulin V, Castilloux G, Auger FA, Garrel D, O'Connor-McCourt MD, Germain L (1998) Modulated response to cytokines of human wound healing myofibroblasts compared to dermal fibroblasts. Exp Cell Res 238:283PubMedCrossRefGoogle Scholar
- 40.Needleman BW, Ordonez JV, Taramelli D, Alms W, Gayer K, Choi J (1990) In vitro identification of a subpopulation of fibroblasts that produces high levels of collagen in scleroderma patients. Arthritis Rheum 33:842PubMedCrossRefGoogle Scholar
- 41.Ohta K, Mortenson RL, Clark RA, Hirose N, King TE Jr (1995) Immunohistochemical identification and characterization of smooth muscle-like cells in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 152:1659PubMedGoogle Scholar
- 42.Peltonen J, Kahari L, Jaakkola S, Kahari VM, Varga J, Uitto J, Jimenez SA (1990) Evaluation of transforming growth factor-β and type I procollagen gene expression in fibrotic skin diseases by in situ hybridization. J Invest Dermatol 94:365PubMedCrossRefGoogle Scholar
- 43.Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UL Liotta LA, Falanga V, Kehrl JH, Fauci AS (1986) Transforming growth factor type β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 83:4167PubMedCrossRefGoogle Scholar
- 44.Rodemann HP, Bayreuther K, Francz PI, Dittmann K, Albiez M (1989) Selective enrichment and biochemical characterization of seven human skin fibroblasts cell types in vitro. Exp Cell Res 180:84PubMedCrossRefGoogle Scholar
- 45.Rodemann HP, Muller GA (1990) Abnormal growth and clonal proliferation of fibroblasts derived from kidneys with interstitial fibrosis. Proc Soc Exp Biol Med 195:57PubMedGoogle Scholar
- 46.Rodemann HP, Muller GA (1991) Characterization of human renal fibroblasts in health and disease. II. In vitro growth, differentiation, and collagen synthesis of fibroblasts from kidneys with interstitial fibrosis. Am J Kidney Dis 17:684PubMedGoogle Scholar
- 47.Rodemann HP, Muller GA, Knecht A, Norman JT, Fine LG (1991) Fibroblasts of rabbit kidney in culture. I. Characterization and identification of cell-specific markers. Am J Physiol 261:F283PubMedGoogle Scholar
- 48.Scharffetter K, Lankat-Buttgereit B, Krieg T (1988) Localization of collagen mRNA in normal and scleroderma skin by in-situ hybridization. Eur J Clin Invest 18:9PubMedCrossRefGoogle Scholar
- 49.Shichiri M, Sedivy JM, Marumo F, Hirata Y (1998) Endothelin-1 is a potent survival factor for c-Myc-dependent apoptosis. Mol Endocrinol 12:172PubMedCrossRefGoogle Scholar
- 50.Spanakis E, Brouty-Boye D (1997) Discrimination of fibroblast subtypes by multivariate analysis of gene expression. Int J Cancer 71:402PubMedCrossRefGoogle Scholar
- 51.Strehlow D, Jelaska A, Strehlow K, Korn JH (1999) A potential role for protease nexin 1 overexpression in the pathogenesis of scleroderma. J Clin Invest 103:1179PubMedCrossRefGoogle Scholar
- 52.Tabata H, Yamakage A, Yamazaki S (1997) Cutaneous localization of endothelin 1 in patients with systemic sclerosis: immuno-electron microscopic study. Int J Dermatol 36:272PubMedCrossRefGoogle Scholar
- 53.Takemura G, Ohno M, Hayakawa Y, Misao J, Kanoh M, Ohno A, Uno Y, Minatoguchi S, Fujiwara T, Fujiwara H (1998) Role of apoptosis in the disappearance of infiltrated and proliferated interstitial cells after myocardial infarction. Circ Res 82:1130PubMedGoogle Scholar
- 54.Tang L, Tanaka Y, Marumo F, Sato C (1994) Phenotypic change in portal fibroblasts in biliary fibrosis. Liver 14:76PubMedGoogle Scholar
- 55.Taylor L, Polgar P (1977) Self regulation of growth by human diploid fibroblasts via prostaglandin production. FEBS Lett 79:69PubMedCrossRefGoogle Scholar
- 56.Trojanowska M, Wu LT, LeRoy EC (1988) Elevated expression of c-myc protooncogene in scleroderma fibroblasts. Oncogene 3:477PubMedGoogle Scholar
- 57.Varga J, Rosenbloom J, Jimenez SA (1987) Transforming growth factor-β (TGF-β1) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs; in normal human dermal fibroblasts. Biochem J 247:597PubMedGoogle Scholar
- 58.Worrall JG, Whiteside TL, Prince RK, Buckingham RB, Stachura I, Rodnan GP (1986) Persistence of scleroderma-like phenotype in normal fibroblasts after prolonged exposure to soluble mediators from mononuclear cells. Arthritis Rheum 29:54PubMedCrossRefGoogle Scholar
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