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The role of invariant T cells in inflammation of the skin and airways

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Abstract

Invariant and semi-invariant T cells are emerging as important regulators of host environment interactions at barrier tissues such as the airway and skin. In contrast to conventional T cells, invariant natural killer T (iNKT) cells and mucosal associated invariant T (MAIT) cells express T cell receptors of very limited diversity. iNKT and MAIT cells recognise antigens presented by the MHC class 1-like monomorphic molecules CD1d and MR1, respectively. Both iNKT cells and MAIT cells have been identified in the skin and airways and can rapidly produce cytokines after activation. Numerous studies have implicated iNKT cells in the pathology of both skin and airway disease, but conflicting evidence in human disease means that more studies are necessary to resolve the exact roles of iNKT in inflammation. The functions of MAIT cells in skin and lung inflammation are even less well defined. We herein describe the current literature on iNKT and MAIT cells in allergic and non-allergic skin diseases (dermatitis and psoriasis) and airway diseases (asthma, chronic obstructive pulmonary disease, rhinitis, and chronic rhinosinusitis).

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Authors and Affiliations

  1. Centre for Cancer Biology, The University of South Australia and SA Pathology, North Terrace, Adelaide, SA, 5000, Australia

    Kwok Ho Yip, Harshita Pant & Damon J. Tumes

  2. Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba, 260-8670, Japan

    Magdalene Papadopoulos & Damon J. Tumes

  3. Department of Otolaryngology, Head and Neck Surgery, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia

    Harshita Pant

  4. South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA, 5000, Australia

    Damon J. Tumes

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This article is a contribution to the special issue on The Pathogenicity of Acquired Immunity in Human Diseases - Guest Editor: Kiyoshi Hirahara

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Yip, K.H., Papadopoulos, M., Pant, H. et al. The role of invariant T cells in inflammation of the skin and airways. Semin Immunopathol 41, 401–410 (2019). https://doi.org/10.1007/s00281-019-00740-9

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