Seminars in Immunopathology

, Volume 40, Issue 6, pp 539–543 | Cite as

IgA nephropathy: clearance kinetics of IgA-containing immune complexes

  • Ann ChenEmail author
  • Sung-Sen Yang
  • Tsai-Jung Lin
  • Shuk-Man Ka


IgA nephropathy (IgAN) is associated predominantly IgA deposition in the affected glomeruli and has been shown to be the most common glomerular disorder among young people in the world. Although the exact pathogenic mechanism underlying IgAN remains largely unknown, circulating IgA-containing immune complexes (IgA ICs) is considered to play a major role in initiating the development and evolution of the renal disorder. In this review article, we discuss the fundamental mechanisms of clearance kinetics of IgA ICs and related issues, covering the following: (1) role of circulating IgA ICs in the pathogenesis of IgAN and (2) elimination of IgA ICs from the body, with emphasis of the role of the liver and Fc receptors in immune cells.


IgA nephropathy IgA immune complex Clearance kinetics Mononuclear phagocyte Kupffer cell Fc receptor CD89 (Fc alpha/muR) 


Funding information

This work was supported by grants Ministry of National Defense—Medical Affairs Bureau—MAB-106-007 from the National Defense Medical Center and TSGH-C107-063 from the Tri-Service General Hospital, Taipei, Taiwan.

Compliance with ethical standards

Competing interests

The authors declare that they have no competing interests.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Ann Chen
    • 1
    Email author
  • Sung-Sen Yang
    • 2
    • 3
  • Tsai-Jung Lin
    • 1
  • Shuk-Man Ka
    • 4
  1. 1.Department of PathologyTri-Service General Hospital, National Defense Medical CenterTaipeiTaiwan
  2. 2.Graduate Institute of Medical SciencesNational Defense Medical CenterTaipeiTaiwan
  3. 3.Division of Nephrology, Department of Internal MedicineTri-Service General Hospital, National Defense Medical CenterTaipeiTaiwan
  4. 4.Graduate Institute of Aerospace and Undersea MedicineNational Defense Medical CenterTaipeiTaiwan

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