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Innate lymphoid cells in autoimmunity and chronic inflammatory diseases

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Abstract

Abnormal activation of the innate immune system is a common feature of autoimmune and chronic inflammatory diseases. Since their identification as a separate family of leukocytes, innate lymphoid cells (ILCs) have emerged as important effector cells of the innate immune system. Alterations in ILC function and subtype distribution have been observed in a variety of immune-mediated diseases in humans and evidence from experimental models suggests a subtype specific role of ILCs in the pathophysiology of autoimmune inflammation. In this review, we discuss recent advances in the understanding of ILC biology in autoimmune and chronic inflammatory disorders, including multiple sclerosis, inflammatory bowel diseases, psoriasis, and rheumatic diseases, with a special focus on the potential of ILCs as therapeutic targets for the development of novel treatment strategies in humans.

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Acknowledgements

We thank Martina Becker for the excellent help with preparing the figures.

Funding

J.-E.T. is supported by an Emmy Noether Grant of the Deutsche Forschungsgemeinschaft (TU316/1-2) and by the Collaborative Research Center 1192 “Immune-Mediated Glomerular Diseases” funded by the Deutsche Forschungsgemeinschaft.

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  1. III. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany

    Tingting Xiong & Jan-Eric Turner

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  1. Tingting Xiong
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  2. Jan-Eric Turner
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Correspondence to Jan-Eric Turner.

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This article is a contribution to the special issue on Innate Lymphoid Cells in Inflammation and Immunity - Guest Editors: Jan-Eric Turner and Georg Gasteiger

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Xiong, T., Turner, JE. Innate lymphoid cells in autoimmunity and chronic inflammatory diseases. Semin Immunopathol 40, 393–406 (2018). https://doi.org/10.1007/s00281-018-0670-4

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