Seminars in Immunopathology

, Volume 37, Issue 3, pp 221–231 | Cite as

Pathogenic CD8+ T cells in experimental cerebral malaria

  • Shanshan Wu Howland
  • Carla Claser
  • Chek Meng Poh
  • Sin Yee Gun
  • Laurent RéniaEmail author


Cerebral malaria (CM) is one the major complications occurring during malaria infection. The mechanisms leading to this syndrome are still not completely understood. Although it is clear that parasite sequestration is the key initiation factor, the downstream pathological processes are still highly debated. The experimental cerebral malaria (ECM) model, in which susceptible mice are infected with Plasmodium berghei ANKA, has led to the identification of CD8+ T cells as the major mediator of ECM death. In this review, we discuss the recent advances and future developments in the understanding of the role of CD8+ T cells in CM.


Malaria CD8+ T cells Brain Pathology 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Shanshan Wu Howland
    • 1
  • Carla Claser
    • 1
  • Chek Meng Poh
    • 1
    • 2
  • Sin Yee Gun
    • 1
    • 2
  • Laurent Rénia
    • 1
    • 2
    Email author
  1. 1.Singapore Immunology NetworkAgency for Science, Technology and Research (A*STAR)SingaporeSingapore
  2. 2.Department of Microbiology, Life Sciences Institute, Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore

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