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Seminars in Immunopathology

, Volume 36, Issue 2, pp 137–148 | Cite as

From proliferation to proliferation: monocyte lineage comes full circle

  • Filip K. SwirskiEmail author
  • Ingo Hilgendorf
  • Clinton S. Robbins
Review

Abstract

Monocytes are mononuclear circulating phagocytes that originate in the bone marrow and give rise to macrophages in peripheral tissue. For decades, our understanding of monocyte lineage was bound to a stepwise model that favored an inverse relationship between cellular proliferation and differentiation. Sophisticated molecular and surgical cell tracking tools have transformed our thinking about monocyte topo-ontogeny and function. Here, we discuss how recent studies focusing on progenitor proliferation and differentiation, monocyte mobilization and recruitment, and macrophage differentiation and proliferation are reshaping knowledge of monocyte lineage in steady state and disease.

Keywords

Monocyte Hematopoiesis Macrophage Proliferation Atherosclerosis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Filip K. Swirski
    • 1
    Email author
  • Ingo Hilgendorf
    • 1
  • Clinton S. Robbins
    • 2
  1. 1.Center for Systems Biology, Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  2. 2.Toronto General Research Institute, Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular ResearchUniversity of TorontoTorontoCanada

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