Seminars in Immunopathology

, Volume 34, Issue 6, pp 863–871 | Cite as

Th2 responses in schistosomiasis

  • Keke Fairfax
  • Marcia Nascimento
  • Stanley Ching-Cheng Huang
  • Bart Everts
  • Edward J. PearceEmail author


Schistosomiasis is caused by infection with parasitic flatworms of the genus Schistosoma. It is characterized by the development of strong CD4+ T cell and B cell responses that, during primary infection, fail to eliminate the parasites, but in collaboration with cells of the innate immune system allow survival in the face of ongoing tissue damage caused by the lodging of parasite eggs in the liver and the passage of eggs across the intestinal epithelium. Mounting a tightly controlled Th2 response is key to this outcome, and while this type of response is a risk factor for the development of fibrosis, it also underpins the development of resistance to further infection; as such, understanding how Th2 responses are induced and regulated in schistosomiasis remains a critical area of research.


Helminth Parasite Th2 Fibrosis Macrophage Treg Tfh Eosinophil Immunopathology 



Work in the Pearce laboratory is supported by the NIH (to EJP) and by Merck-UNCF to KF.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Keke Fairfax
    • 1
  • Marcia Nascimento
    • 1
  • Stanley Ching-Cheng Huang
    • 1
  • Bart Everts
    • 1
  • Edward J. Pearce
    • 1
    • 2
    Email author
  1. 1.Division of Immunobiology, Department of Pathology and ImmunologyWashington University School of MedicineSt. LouisUSA
  2. 2.St. LouisUSA

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