Seminars in Immunopathology

, Volume 34, Issue 5, pp 715–731 | Cite as

Eosinophilic gastrointestinal diseases—clinically diverse and histopathologically confounding

  • Seema Aceves
  • Ikuo Hirano
  • Glenn T. Furuta
  • Margaret H. Collins


Eosinophilic gastrointestinal diseases are a group of chronic diseases characterized by a range of symptoms caused by eosinophilic inflammation of various parts of the gastrointestinal tract. Other causes for eosinophilia need to be ruled out prior to making the diagnosis of EGIDs. The most common form of EGID is eosinophilic esophagitis (EoE), an antigen-driven disease that afflicts children and adults and has been identified across the world. Histological features include dense eosinophilia of the esophageal mucosa, eosinophil degranulation, eosinophil microabscess formation, and other features of epithelial inflammation including basal zone hyperplasia and rete pege elongation. Treatments include dietary exclusions and topical corticosteroids.


Eosinophilic esophagitis Gastrointestinal allergy Esophagitis 



We would like to thank Chris Woods for expert microphotographic assistance. We thank Lindsay Hosford for her expertise in immunohistochemical staining.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Seema Aceves
    • 1
    • 2
  • Ikuo Hirano
    • 3
  • Glenn T. Furuta
    • 4
  • Margaret H. Collins
    • 5
    • 6
  1. 1.Division of Allergy, Immunology, Departments of Pediatrics and MedicineUniversity of California, San DiegoLa JollaUSA
  2. 2.Rady Children’s HospitalSan DiegoUSA
  3. 3.Division of Gastroenterology, Department of MedicineNorthwestern University Feinberg School of MedicineChicagoUSA
  4. 4.Department of PediatricsUniversity of Colorado Denver School of Medicine Digestive Health Institute Gastrointestinal Eosinophilic Diseases Program Mucosal Inflammation Program Children’s Hospital ColoradoDenverUSA
  5. 5.Department of PathologyUniversity of CincinnatiCincinnatiUSA
  6. 6.Cincinnati Children’s Hospital Medical CenterCincinnatiUSA

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