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Seminars in Immunopathology

, Volume 34, Issue 3, pp 353–364 | Cite as

Sialoadhesin in recognition of self and non-self

  • Mariliis Klaas
  • Paul R. CrockerEmail author
Review

Abstract

The immune system is tightly regulated to maintain an appropriate balance between immune activation and tolerance. Macrophages play a key role in this process since they express many pathogen recognition molecules as well as receptors for ‘self’. Sialoadhesin is a major macrophage receptor that specifically recognizes sialic acid, an abundant component of host glycoconjugates but which can also be found on several human pathogens. In recent years, several studies have demonstrated that sialoadhesin can contribute to the uptake and processing of sialylated pathogens as well as playing an important role in regulating inflammatory and autoimmune responses via recognition of self.

Keywords

Sialoadhesin Sialic acid Innate immunity Pathogens 

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Division of Cell Signalling and Immunology, College of Life SciencesUniversity of DundeeDundeeUK

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