Seminars in Immunopathology

, Volume 34, Issue 1, pp 151–165

Interactions between coagulation and complement—their role in inflammation

  • Katerina Oikonomopoulou
  • Daniel Ricklin
  • Peter A. Ward
  • John D. Lambris
Review

DOI: 10.1007/s00281-011-0280-x

Cite this article as:
Oikonomopoulou, K., Ricklin, D., Ward, P.A. et al. Semin Immunopathol (2012) 34: 151. doi:10.1007/s00281-011-0280-x

Abstract

The parallel expression of activation products of the coagulation, fibrinolysis, and complement systems has long been observed in both clinical and experimental settings. Several interconnections between the individual components of these cascades have also been described, and the list of shared regulators is expanding. The co-existence and interplay of hemostatic and inflammatory mediators in the same microenvironment typically ensures a successful host immune defense in compromised barrier settings. However, dysregulation of the cascade activities or functions of inhibitors in one or both systems can result in clinical manifestations of disease, such as sepsis, systemic lupus erythematosus, or ischemia–reperfusion injury, with critical thrombotic and/or inflammatory complications. An appreciation of the precise relationship between complement activation and thrombosis may facilitate the development of novel therapeutics, as well as improve the clinical management of patients with thrombotic conditions that are characterized by complement-associated inflammatory responses.

Keywords

Anaphylatoxin Coagulation Complement Fibrinolysis Inflammation Sepsis 

Abbreviations

aHUS

Atypical hemolytic uremic syndrome

C1INH

C1 inhibitor

C4BP

C4b-binding protein

C3aR

C3a receptor

C5aR

C5a receptor

C5L2

C5a receptor-like 2

DAF

Decay accelerating factor

DIC

Disseminated intravascular coagulation

DSS

Dextran sulphate sodium

HAE

Hereditary angioedema

HMGB1

High mobility globulin B1

IBD

Inflammatory bowel disease

IL

Interleukin

LPS

Lipopolysaccharide

MAC

Membrane-attack complex

MASP

Mannose-binding lectin-associated serine proteinase

MBL

Mannose-binding lectin

MCP-1

Monocytes chemoattractant protein 1

MIF

Migration-inhibitory factor

MIP-1

Macrophage inflammatory protein 1

PAI-1

Plasminogen activator inhibitor 1

PAR

Proteinase-activated receptor

PNH

Paroxysmal nocturnal hemoglobinuria

SIRS

Systemic inflammatory response syndrome

SLE

Systemic lupus erythematosus

TAFI

Thrombin activatable fibrinolysis inhibitor

TF

Tissue factor

TNF

Tumor necrosis factor

tPA

Tissue plasminogen activator

uPA

Urokinase plasminogen activator

uPAR

Urokinase plasminogen activator receptor

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Katerina Oikonomopoulou
    • 1
  • Daniel Ricklin
    • 1
  • Peter A. Ward
    • 2
  • John D. Lambris
    • 1
  1. 1.Department of Pathology & Laboratory Medicine, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of PathologyUniversity of Michigan Medical SchoolAnn ArborUSA

Personalised recommendations