Seminars in Immunopathology

, Volume 33, Issue 6, pp 525–534

How to cross immunogenetic hurdles to human embryonic stem cell transplantation

Review

Abstract

Implantation of human embryonic stem cells (hES), derived progenitors or mature cells derived from hES has great therapeutic potential for many diseases. If hES would come from genetically unrelated individuals, it would be probably rejected by the immune system of the recipient. Blood groups, MHC and minor antigens are the immunogenetic hurdles that have to be crossed for successful transplantation. Autologous transplantation with adult stem cells would be the best approach but several elements argue against this option. Classical immunosuppression, depleting antibody, induction of tolerance and stem cell banking are alternative methods that could be proposed to limit the risk of rejection.

Keywords

Embryonic stem transplantation MHC Minor antigen Rejection Immunosuppression 

Abbreviations

hES

Human embryonic stem cells

NK

Natural killer

MHC

Major histocompatibility complex class

HLA

Human leukocyte antigen

mHC

Minor histocompatibility antigen

GvHD

Graft-versus-host disease

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Transplant Immunology Unit, Division of Immunology and Allergy and Division of Laboratory MedicineGeneva University Hospital and Medical SchoolGeneva 14Switzerland

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