Seminars in Immunopathology

, Volume 32, Issue 3, pp 227–238 | Cite as

Dynamics of dendritic cell–T cell interactions: a role in T cell outcome

  • Stéphanie HuguesEmail author


Antigen-specific dendritic cells (DC)–T cell encounters occur in lymph nodes (LNs) and are essential for the induction of both priming and tolerance. In both cases, T cells are rapidly activated and proliferate. However, the subsequent outcome of T cell activation depends on the modulation of different DC- and T cell-intrinsic signals. Recent advances in two-photon (2P) microscopy have furthered our understanding regarding the complex choreography of DCs and T cells in intact LNs, and established differences in the dynamics of DC–T cell contacts during priming and tolerance induction. The mechanisms that favour DC–T cell encounters, as well as the contribution of the frequency and the duration of such encounters in dictating the T cell response, are discussed in this review.


Dendritic cells T cells Dynamic interactions Priming Tolerance Lymph node 



The author thanks W. Ferlin, C. Ody and W. Reith for the critical reading of this manuscript. This work is supported by the Swiss National Science Foundation (grant 310030–127042).


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© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of PathologyUniversity of Geneva Medical SchoolGenevaSwitzerland

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