Seminars in Immunopathology

, Volume 32, Issue 2, pp 127–136 | Cite as

Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases

  • Stephanie M. Stanford
  • Tomas M. Mustelin
  • Nunzio BottiniEmail author


A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical negative modulator of TCR signaling encoded by the PTPN22 gene. The functional analysis of autoimmune-associated PTPN22 genetic variants suggests that genetic variability of TCR signal transduction contributes to the pathogenesis of autoimmunity in humans.


PTPN22 LYP Pep Csk Lck TCR signaling Tyrosine phosphatase Autoimmunity 



This work was supported by NIH grant R01AI070544 to N.B. This is publication #1257 from the La Jolla Institute for Allergy and Immunology.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Stephanie M. Stanford
    • 1
  • Tomas M. Mustelin
    • 2
  • Nunzio Bottini
    • 1
    Email author
  1. 1.Division of Cell BiologyLa Jolla Institute for Allergy and ImmunologyLa JollaUSA
  2. 2.Sanford-Burnham Medical Research Institute, Infectious and Inflammatory Disease CenterLa JollaUSA

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