Seminars in Immunopathology

, Volume 30, Issue 2, pp 121–126 | Cite as

Immunological mechanisms in glaucoma

  • F. GrusEmail author
  • D. Sun


Glaucoma is one of the most frequent causes of blindness worldwide. The elevated intraocular pressure does not explain glaucoma in all patients but can be considered as a risk factor of the disease. There are some evidences that autoimmune mechanisms may be involved in this disorder. This review attempts to demonstrate the findings about autoimmune mechanisms in glaucoma patients. Consistent up- and down-regulations in the autoantibody profiles against ocular antigens are present in glaucoma patients. These changes in natural autoimmunity could be found in independent study populations and might be a promising tool for glaucoma detection.


Glaucoma Autoimmunity Autoantibodies Natural autoimmunity 


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Experimental Ophthalmology, Department of OphthalmologyUniversity of MainzMainzGermany
  2. 2.Department Of Ophthalmology and Vision CenterUniversity of LouisvilleLouisvilleUSA
  3. 3.MainzGermany

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