Seminars in Immunopathology

, Volume 29, Issue 2, pp 123–133

UNK cells: their role in tissue re-modelling and preeclampsia



In different species of mammal, uterine natural killer (uNK) cells are massively recruited and presented at the fetal maternal interface with a spatio-temporal pattern, and regarded as a constructive element to support reproductive development. Recent insights highlight the uNK cells activation, function and interaction with local compartments, which all contribute to the initiation of vascular structural changes. New trends of uNK cells research will benefit the diagnosis, management and test treatment strategy of preeclampsia. Furthermore, we suggest that more efforts and specific studies are needed to further explore the role of uNK cells at the unique micro-environment.


uNK cells Preeclampsia Spiral artery Trophoblast Pregnancy 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Institute of Immunology, Hefei National Laboratory for Physical Sciences at MicroscaleUniversity of Science and Technology of ChinaHefeiChina
  2. 2.School of Life SciencesUniversity of Science and Technology of ChinaHefeiChina

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