Disturbances in placental immunology: ready for therapeutic interventions?

  • Sinuhe Hahn
  • Anurag Kumar Gupta
  • Carolyn Troeger
  • Corinne Rusterholz
  • Wolfgang Holzgreve
Original Article

DOI: 10.1007/s00281-006-0016-5

Cite this article as:
Hahn, S., Gupta, A.K., Troeger, C. et al. Springer Semin Immun (2006) 27: 477. doi:10.1007/s00281-006-0016-5

Abstract

Recent studies have provided new insight into aberrations in the immunological interplay between mother and fetus and their potential role in the development of recurrent fetal loss and preeclampsia. The action of anti-phospholipid antibodies in recurrent fetal loss is now proposed to involve the complement system, neutrophil activation and the production of TNFα by immune bystander cells. A clear involvement of the immune system is emerging in preeclampsia, involving mainly the innate arm, especially neutrophils. The activation of peripheral neutrophils by placentally released inflammatory debris triggers the induction of neutrophil extracellular traps (NETs), which may lead to an occlusion of the intervillous space, thereby further promoting a condition of placental hypoxia. It has, hence, been suggested that new therapeutic strategies be developed, including the possible use of TNFα antagonists in cases of recurrent miscarriage. These strategies need to be addressed with caution due to the possible induction of fetal congenital abnormalities.

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Sinuhe Hahn
    • 1
  • Anurag Kumar Gupta
    • 1
  • Carolyn Troeger
    • 1
  • Corinne Rusterholz
    • 1
  • Wolfgang Holzgreve
    • 1
  1. 1.Laboratory for Prenatal Medicine, University Women’s Hospital, Department of ResearchUniversity of BaselBaselSwitzerland

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