Springer Seminars in Immunopathology

, Volume 26, Issue 4, pp 377–383 | Cite as

Innate-like B cells

  • John F. Kearney
Original Article


Numerous studies in several species have shown that certain subsets of T and B lymphocytes express antigen receptors which are either semi-invariant, or germline encoded, and often autoreactive. In the case of B cells they appear to use a distinct immune recognition strategy during developmental selection and functional activation. These B cells respond to foreign antigens, and have the ability to protect against a variety of infections; however, they can also react with self or neoself antigens. They appear to use the latter as positively selecting ligands facilitating their entry into and maintenance in a functional repertoire, as well as providing cues for positioning themselves in strategic microenvironmental niches in the immune system and at interfaces with the environment. These innate-like B cell subsets form a bridge between the rapidly occurring innate immune responses, and the slower acting primary, T cell-dependent, adaptive antibody response by providing a rapid T cell-independent antibody response.


B cells Phosphorylcholine TEPC15 ApoE 


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Division of Developmental and Clinical Immunology, Department of MicrobiologyUniversity of Alabama at BirminghamBirminghamUSA

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