Cancer Chemotherapy and Pharmacology

, Volume 48, Issue 5, pp 413–416 | Cite as

Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice

  • Henry S. Friedman
  • Stephen T. Keir
  • Peter J. Houghton
  • Amy A. Lawless
  • Darell D. Bigner
  • Stephen J. Waters
Original Article

Abstract.

Purpose: This study was conducted to define the activity of irofulven in the treatment of a series of xenografts derived from human glioblastoma multiforme growing subcutaneously and intracranially in athymic nude mice. Methods: Athymic mice bearing subcutaneous or intracranial tumors were treated with irofulven at a 10% lethal dose with responses compared to tumor-bearing mice treated with drug vehicle. Results: Irofulven was active against all tumor lines tested with growth delays ranging from 5.6 to 81.6 days (all values statistically significant, P≤0.001). Irofulven also produced a statistically significant (P≤0.001) increase in the median survival of mice bearing D-456 intracranial xenografts with a 162% increase in median survival. Conclusions: Irofulven is active in a spectrum of human glioblastoma multiforme-derived xenografts and evaluation in patients with this neoplasm is warranted.

Glioblastoma multiforme Irofulven Nude mice Xenografts CNS tumors 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Henry S. Friedman
    • 1
  • Stephen T. Keir
    • 1
  • Peter J. Houghton
    • 3
  • Amy A. Lawless
    • 1
  • Darell D. Bigner
    • 2
  • Stephen J. Waters
    • 4
  1. 1.Department of Surgery, Duke University Medical Center, PO Box 3624, Durham, NC 27710USA
  2. 2.Department of Pathology, Duke University Medical Center, Durham, NC 27710USA
  3. 3.Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38105USA
  4. 4.Research and Development, MGI-PHARMA Inc., Bloomington, MN 55438USA

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