Cancer Chemotherapy and Pharmacology

, Volume 83, Issue 5, pp 881–892 | Cite as

Safety assessment of anticancer drugs in association with radiotherapy in metastatic malignant melanoma: a real-life report

Radiation/systemic drug combo in metastatic melanoma
  • Emmanuelle Couty
  • Alexis Vallard
  • Sandrine Sotton
  • Sarra Ouni
  • Max-Adrien Garcia
  • Sophie Espenel
  • Chloe Rancoule
  • Majed Ben Mrad
  • Anne-Catherine Biron
  • Jean-Luc Perrot
  • Julien Langrand-Escure
  • Nicolas MagnéEmail author
Original Article



To assess the safety of the association of radiotherapy (RT) and systemic treatments for patients with metastatic malignant melanoma (mMM).


A retrospective analysis included consecutive patients treated with palliative RT, and at least one line of systemic therapy for mMM between 2001 and 2016. Treatments were defined as sequential or concomitant when RT and the systemic drug were administered, respectively, at more or less than five half-lives from each other.


92 patients were included. They had 110 palliative RT treatments. RT was delivered with a “conventional” chemotherapy (mainly fotemustine and/or dacarbazine) and a “modern” systemic therapy (BRAF inhibitors, association of BRAF and MEK inhibitors, immunotherapy), respectively, in 88 (80%) and 22 (20%) cases. Systemic treatments and RT were mainly concurrently performed (n = 61, 55.5%). Regarding acute grade ≥ 3 toxicity, no difference was reported between sequential and concomitant groups either in the whole cohort (p = 1) or in the subgroup of patients receiving “modern” systemic therapies (p = 1). Acute and late grade ≥ 3 toxicities only occurred with vemurafenib. BRAF inhibitors and RT produced more severe infield adverse events than other associations (p = 0.001) with two deaths.


In our series, compared to sequential administration, concomitant association of systemic anticancer drugs and palliative RT did not increase toxicity in mMM patients. BRAF inhibitors and RT produced severe infield toxicities. Prospective studies are needed to better characterize the toxicity of each association.


Melanoma Radiation therapy Systemic drugs Toxicity 


Compliance with ethical standards

Conflict of interest

Authors declare having no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Emmanuelle Couty
    • 1
  • Alexis Vallard
    • 2
  • Sandrine Sotton
    • 2
  • Sarra Ouni
    • 2
  • Max-Adrien Garcia
    • 3
  • Sophie Espenel
    • 2
    • 4
  • Chloe Rancoule
    • 2
    • 4
  • Majed Ben Mrad
    • 2
  • Anne-Catherine Biron
    • 1
  • Jean-Luc Perrot
    • 1
  • Julien Langrand-Escure
    • 2
  • Nicolas Magné
    • 2
    • 4
    Email author
  1. 1.Dermatology DepartmentUniversity Hospital Nord Saint EtienneSt Priest en JarezFrance
  2. 2.Institut de Cancérologie Lucien NeuwirthSt Priest en Jarez cedexFrance
  3. 3.Public Health DepartmentLucien Neuwirth Cancer InstituteSt Priest en JarezFrance
  4. 4.Cellular and Molecular Radiobiology Laboratory, CNRS UMR 5822, IPNLVilleurbanneFrance

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