Metastatic or locally advanced breast cancer patients: towards an expert consensus on nab-paclitaxel treatment in HER2-negative tumours—the MACBETH project

  • Marina E. Cazzaniga
  • E. Ciruelos
  • A. Fabi
  • J. Garcia-Saenz
  • H. Lindman
  • D. Mavroudis
  • C. Schem
  • G. Steger
  • E. Timotheadou
  • K. Zaman
  • V. Torri
  • on behalf of the MACBETH Group
Original Article



Despite the large use of nab-paclitaxel as a treatment option in metastatic breast cancer (MBC) across different countries, no definitive data are available in particular clinical situations.

Areas covered

Efficacy, safety and schedule issues concerning available literature on nab-paclitaxel in advanced breast cancer and in specific subgroups of patients have been discussed and voted during an International Expert Meeting. Ten expert specialists in oncology, with extensive clinical experience on Nab-P and publications in the field of MBC have been identified. Six scientific areas of interest have been covered, generating 13 specific Statements for Nab-P, after literature review. For efficacy issues, a summary of research quality was performed adopting the GRADE algorithm for evidence scoring. The panel members were invited to express their opinion on the statements, in case of disagreement all the controversial opinions and the relative motivations have been made public.

Expert opinion

Consensus was reached in 30.8% of the Nab-P statements, mainly those regarding safety issues, whereas ones regarding efficacy and schedule still remain controversial areas, requiring further data originated by the literature.


Expert meeting Nab-paclitaxel Breast cancer Weekly schedule Neuropathy 




Compliance with ethical standards

Conflict of interest

All the authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Marina E. Cazzaniga
    • 1
    • 2
  • E. Ciruelos
    • 3
  • A. Fabi
    • 4
  • J. Garcia-Saenz
    • 5
  • H. Lindman
    • 6
  • D. Mavroudis
    • 7
  • C. Schem
    • 8
  • G. Steger
    • 9
  • E. Timotheadou
    • 10
  • K. Zaman
    • 11
  • V. Torri
    • 12
  • on behalf of the MACBETH Group
  1. 1.Phase 1 Trials Research Unit and Oncology UnitASST Monza and Milano Bicocca School of MedicineMonzaItaly
  2. 2.Oncology UnitASST MonzaMonzaItaly
  3. 3.Unidad de Cáncer de Mama del Centro Integral Oncológico Clara Campal HM CIOCCMadridSpain
  4. 4.Medical OncologyRegina Elena National Cancer InstituteRomeItaly
  5. 5.Department of Medical OncologyIdISSC. CIBERONC-ISCIII, Hospital Clínico San CarlosMadridSpain
  6. 6.Department of Immunology, Genetics and PathologyUniversity of UppsalaUppsalaSweden
  7. 7.Department of Medical OncologyUniversity Hospital of HeraklionHeraklionGreece
  8. 8.MammazentrumHamburgGermany
  9. 9.Department of Internal Medicine IMedical University of ViennaViennaAustria
  10. 10.Aristotle University of Thessaloniki School of MedicinePapageorgiou Gen. HospitalThessaloníkiGreece
  11. 11.Breast Center, Department of OncologyUniversity Hospital CHUVLausanneSwitzerland
  12. 12.Istituto IRCCS Istituto Mario NegriMilanItaly

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