Cancer Chemotherapy and Pharmacology

, Volume 80, Issue 3, pp 575–582 | Cite as

Efficacy and safety of taxane monotherapy in advanced gastric cancer refractory to triplet chemotherapy with docetaxel, cisplatin, and S-1: a multicenter retrospective study

  • Sakura Iizumi
  • Atsuo Takashima
  • Yukiya Narita
  • Masahiro Tajika
  • Kei Muro
  • Sadayuki Kawai
  • Hirofumi Yasui
  • Tomohiro Matsushima
  • Daisuke Takahari
  • Kengo Nagashima
  • Narikazu Boku
Original Article

Abstract

Purpose

Taxane monotherapy is widely used for advanced gastric cancer (AGC) after failure of standard first-line chemotherapy with fluoropyrimidine and cisplatin. Triplet chemotherapy with docetaxel, cisplatin, and S-1 (DCS) is a promising regimen for first-line chemotherapy of AGC. The aim of this study was to evaluate the efficacy of taxane monotherapy in patients refractory to DCS.

Methods

We retrospectively evaluated the efficacy and safety of taxane monotherapy in patients with AGC refractory to first-line therapy with DCS between January 2010 and April 2015. Selection criteria were as follows: ECOG PS of 0–2, treatment with taxane monotherapy in second-line or third-line therapy after failure of second-line irinotecan, absence of massive ascites, and adequate organ function.

Results

A total of 30 patients were included in this study. Of these, 15 patients received paclitaxel while another 15 received nanoparticle albumin-bound paclitaxel in either second- or third-line treatment. Median age for the second/third-line group was 64.0/62.0 (range 27–75/42–75); 14/13 (93.3/86.7%) had ECOG PS of 0 or 1. No patients achieved complete or partial response and stable disease was observed in 37.5/35.7% of the patients in the second/third line. Median progression-free survival and overall survival were 3.4 and 5.8 months in the second-line group, and 2.0 and 4.5 months in the third-line group, respectively. The incidences of any grade ≥3 adverse events in the second-line group and the third-line group were 60.0 and 33.3%, respectively. There was no treatment-related death.

Conclusions

Taxane monotherapy after DCS failure had acceptable toxicities but was ineffective in AGC patients.

Keywords

Stomach neoplasms Drug therapy Docetaxel Paclitaxel Albumin-bound paclitaxel 

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Division of Gastrointestinal Medical OncologyNational Cancer Center HospitalTokyoJapan
  2. 2.Keio University Graduate School of MedicineTokyoJapan
  3. 3.Department of Clinical OncologyAichi Cancer Center HospitalNagoyaJapan
  4. 4.Department of EndoscopyAichi Cancer Center HospitalNagoyaJapan
  5. 5.Department of Gastrointestinal OncologyShizuoka Cancer CenterShizuokaJapan
  6. 6.Department of GastroenterologyCancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyoJapan
  7. 7.Department of Global Clinical Research, Graduate School of MedicineChiba UniversityChibaJapan

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