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Cancer Chemotherapy and Pharmacology

, Volume 80, Issue 1, pp 187–193 | Cite as

Clinical significance of systemic chemotherapy after curative resection of metachronous pulmonary metastases from colorectal cancer

  • Sungwoo Park
  • Byung Woog KangEmail author
  • Soo Jung Lee
  • Shinkyo Yoon
  • Yee Soo Chae
  • Jong Gwang Kim
  • Kyung Hee Lee
  • Sung Ae Koh
  • Hong Suk Song
  • Keon Uk Park
  • Jin Young Kim
  • Mi Hwa Heo
  • Hun Mo Ryoo
  • Yoon Young Cho
  • Jungmin Jo
  • Jung Lim Lee
  • Sun Ah Lee
Original Article
  • 264 Downloads

Abstract

Purpose

The use of systemic chemotherapy after resection remains controversial in patients with resectable metachronous pulmonary metastases from colorectal cancer (CRC). This retrospective study compared systemic chemotherapy with observation alone after resection of pulmonary metastases from CRC.

Methods

Between 2001 and 2015, 91 patients with metachronous pulmonary metastases underwent curative surgical resection at five centers. Patients with stage IV at diagnosis were excluded. Overall survival (OS) was defined as the time from pulmonary resection until death. The disease-free interval (DFI) was defined as the time from pulmonary resection until recurrence or death.

Results

Among the 91 patients, 63 were in the chemotherapy group, while 28 were in the observation alone group. The characteristics were similar between the two groups, except for the carcinoembryonic antigen level after pulmonary metastases and the use of adjuvant treatment after resection of the primary tumor. With a median follow-up duration of 46 months (11–126), the estimated 5-year DFI and OS rates were 32.8 and 61.4%, respectively. The chemotherapy following pulmonary resection was not significantly associated with the DFI (p = 0.416) and OS (p = 0.119).

Conclusion

Systemic chemotherapy after pulmonary resection was not found to have a significant effect on survival.

Keywords

Chemotherapy Colorectal cancer Neoplasm metastasis Carcinoembryonic antigen 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Sungwoo Park
    • 1
  • Byung Woog Kang
    • 1
    • 6
    Email author
  • Soo Jung Lee
    • 1
  • Shinkyo Yoon
    • 1
  • Yee Soo Chae
    • 1
  • Jong Gwang Kim
    • 1
  • Kyung Hee Lee
    • 2
  • Sung Ae Koh
    • 2
  • Hong Suk Song
    • 3
  • Keon Uk Park
    • 3
  • Jin Young Kim
    • 3
  • Mi Hwa Heo
    • 3
  • Hun Mo Ryoo
    • 4
  • Yoon Young Cho
    • 4
  • Jungmin Jo
    • 4
  • Jung Lim Lee
    • 5
  • Sun Ah Lee
    • 5
  1. 1.Department of Oncology/HematologyKyungpook National University Hospital, Kyungpook National University, School of MedicineDaeguRepublic of Korea
  2. 2.Department of Hematology-OncologyYeungnam University Medical Center, Yeungnam University College of MedicineDaeguRepublic of Korea
  3. 3.Division of Hematology/Oncology, Department of Internal MedicineKeimyung University Dongsan HospitalDaeguRepublic of Korea
  4. 4.Department of Oncology/HematologyDaegu Catholic University Medical CenterDaeguRepublic of Korea
  5. 5.Department of Oncology/HematologyDaegu Fatima HospitalDaeguRepublic of Korea
  6. 6.Department of Oncology/HematologyKyungpook National University Hospital, Kyungpook National University, School of MedicineDaeguRepublic of Korea

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