Overexpression of ANLN contributed to poor prognosis of anthracycline-based chemotherapy in breast cancer patients



To investigate the associations of ANLN expression with prognosis of breast cancer and clinical outcome of anthracycline-based chemotherapy.


This study enrolled 308 breast cancer patients in which 264 of them received anthracycline-based chemotherapy. Immunohistochemistry was used to detect ANLN expression level of the patients. Clinical characteristics of the patients were collected, and associations of ANLN expression with prognosis were analyzed.


Our results showed that ANLN expression was associated with survival of breast cancer patients, and it was also related to clinical outcome of patients received anthracycline-based chemotherapy. Breast cancer patients with high expression of ANLN would have poor prognosis and poor clinical outcome to anthracycline-based chemotherapy.


ANLN could be an independent prognosis predictor for breast cancer, and its expression might be used to predict the anthracycline-based chemotherapy clinical outcome in breast cancer patients.

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This work was supported by the National Natural Science Foundation of China (81572612) and the Fundamental Research Funds for the Central Universities of Central South University (2015zzts116).

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Correspondence to Wu-Zhong Jiang or Wei-Bing Zhou.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Wang, Z., Chen, J., Zhong, M. et al. Overexpression of ANLN contributed to poor prognosis of anthracycline-based chemotherapy in breast cancer patients. Cancer Chemother Pharmacol 79, 535–543 (2017) doi:10.1007/s00280-017-3248-2

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  • ANLN
  • Breast cancer
  • Anthracycline
  • Prognosis