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Cancer Chemotherapy and Pharmacology

, Volume 71, Issue 6, pp 1619–1627 | Cite as

Potential drug–drug interactions at a referral hematology–oncology ward in Iran: a cross-sectional study

  • Molouk Hadjibabaie
  • Shirinsadat Badri
  • Sarah Ataei
  • Amir Hossein Moslehi
  • Iman KarimzadehEmail author
  • Ardeshir Ghavamzadeh
Original Article

Abstract

Purpose

To assess the pattern and probable risk factors for moderate and major drug–drug interactions in a referral hematology–oncology ward in Iran.

Methods

All patients admitted to hematology–oncology ward of Dr. Shariati Hospital during a 6-month period and received at least two anti-cancer or non-anti-cancer medications simultaneously were included. All being scheduled anti-cancer and non-anti-cancer medications both prescribed and administered during ward stay were considered for drug–drug interaction screening by Lexi-Interact On-Desktop software.

Results

One hundred and eighty-five drug–drug interactions with moderate or major severity were detected from 83 patients. Most of drug–drug interactions (69.73 %) were classified as pharmacokinetics. Fluconazole (25.95 %) was the most commonly offending medication in drug–drug interactions. Interaction of sulfamethoxazole-trimethoprim with fluconazole was the most common drug–drug interaction (27.27 %). Vincristine with imatinib was the only identified interaction between two anti-cancer agents. The number of administered medications during ward stay was considered as an independent risk factor for developing a drug–drug interaction.

Conclusions

Potential moderate or major drug–drug interactions occur frequently in patients with hematological malignancies or related diseases. Performing larger standard studies are required to assess the real clinical and economical effects of drug–drug interactions on patients with hematological and non-hematological malignancies.

Keywords

Drug–drug interactions Hematology–oncology ward Hematological malignancies Iran 

Notes

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Molouk Hadjibabaie
    • 1
  • Shirinsadat Badri
    • 2
  • Sarah Ataei
    • 3
  • Amir Hossein Moslehi
    • 3
  • Iman Karimzadeh
    • 1
    Email author
  • Ardeshir Ghavamzadeh
    • 4
  1. 1.Faculty of Pharmacy and Research Center for Rational Use of DrugsTehran University of Medical SciencesTehranIran
  2. 2.Department of Clinical Pharmacy and Pharmacy Practice, Faculty of PharmacyIsfahan University of Medical SciencesIsfahanIran
  3. 3.Department of Clinical Pharmacy, Faculty of PharmacyTehran University of Medical SciencesTehranIran
  4. 4.Hematology-Oncology and Stem Cell Transplantation Research CenterDr. Shariati Hospital, Tehran University of Medical SciencesTehranIran

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