Cancer Chemotherapy and Pharmacology

, Volume 71, Issue 6, pp 1493–1498 | Cite as

Efficacy of bevacizumab-containing chemotherapy for non-squamous non-small cell lung cancer with bone metastases

  • Takaaki Tokito
  • Takehito Shukuya
  • Hiroaki Akamatsu
  • Tetsuhiko Taira
  • Akira Ono
  • Hirotsugu Kenmotsu
  • Tateaki Naito
  • Haruyasu Murakami
  • Toshiaki Takahashi
  • Masahiro Endo
  • Nobuyuki Yamamoto
Original Article



Skeletal-related events (SREs) negatively affect the quality of life of patients with cancer. Vascular endothelial growth factor receptor (VEGFR)-targeted therapy is effective against bone metastasis in animal models, but the clinical efficacy of anti-VEGFR inhibitors against bone metastases remains unclear. Therefore, we aimed to investigate the efficacy of chemotherapy with bevacizumab, an anti-VEGF antibody, against bone metastases.


We retrospectively reviewed consecutive patients with non-squamous non-small cell lung cancer who received first-line platinum-based chemotherapy with zoledronic acid at Shizuoka Cancer Center between 2007 and 2011.


Of 25 patients, 13 received bevacizumab-based chemotherapy (BEV group) and 12 received chemotherapy without bevacizumab (non-BEV group). The overall response (54 vs. 8 %, p = 0.01) and disease control (100 vs. 50 %, p = 0.01) rates were higher in the BEV group than in the non-BEV group. The bone-specific response (23 vs. 0 %, p = 0.038) and disease control (100 vs. 67 %, p = 0.01) rates were also higher in the BEV group. The median time to progression (TTP) for bone metastases was higher in the BEV group (13.7 vs. 4.3 months, p = 0.06), whereas that for overall disease was similar between the groups (5.7 vs. 2.6 months, p = 0.17). The proportions of patients with SREs were 23 and 50 % in the BEV and non-BEV groups, respectively (p = 0.16).


Bevacizumab might potentiate the antitumor activity of chemotherapy against systemic disease and bone metastases, prolonging bone-specific TTP and reducing the incidence of SRE.


Bone metastases Skeletal-related event Bevacizumab Chemotherapy 



The authors thank Scientific Language for reviewing the English manuscript. No financial support was obtained for this study.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Takaaki Tokito
    • 1
  • Takehito Shukuya
    • 1
  • Hiroaki Akamatsu
    • 1
  • Tetsuhiko Taira
    • 1
  • Akira Ono
    • 1
  • Hirotsugu Kenmotsu
    • 1
  • Tateaki Naito
    • 1
  • Haruyasu Murakami
    • 1
  • Toshiaki Takahashi
    • 1
  • Masahiro Endo
    • 2
  • Nobuyuki Yamamoto
    • 1
  1. 1.Division of Thoracic OncologyShizuoka Cancer Center HospitalNagaizumi-cho, Sunto-gunJapan
  2. 2.Division of Diagnostic RadiologyShizuoka Cancer CenterNagaizumi-cho, Sunto-gunJapan

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