Cancer Chemotherapy and Pharmacology

, Volume 67, Issue 5, pp 1189–1190 | Cite as

The contribution of SK3 polymorphisms to acute oxaliplatin-induced neurotoxicity: direct or indirect effects?

  • Susanna B. Park
  • Cindy S-Y. Lin
  • Arun V. Krishnan
  • Matthew C. Kiernan
Letter to the Editor


Oxaliplatin Channel Function Repetitive Activity Flupirtine Single Action Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Basso M, Modini A, Spada D, Cassano A, Schinzari G, Lo Monaco M, Quaranta D, Tonali PA, Barone C (2010) Polymorphism of CAG motif of SK3 gene is associated with acute oxaliplatin neurotoxicity. Cancer Chemother Pharmacol. doi: 10.1007/s00280-010-1466-y
  2. 2.
    Krishnan AV, Goldstein D, Friedlander M, Kiernan MC (2005) Oxaliplatin-induced neurotoxicity and the development of neuropathy. Muscle Nerve 32:51–60PubMedCrossRefGoogle Scholar
  3. 3.
    Park SB, Lin CS, Krishnan AV, Goldstein D, Friedlander M, Kiernan MC (2009) Oxaliplatin-induced neurotoxicity: changes in axonal excitability precede development of neuropathy. Brain 132:2712–2723PubMedCrossRefGoogle Scholar
  4. 4.
    Park SB, Goldstein D, Lin CS, Krishnan AV, Friedlander M, Kiernan MC (2009) Acute abnormalities of sensory nerve function associated wtih oxaliplatin-induced neurotoxicity. J Clin Oncol 27(8):1243–1249PubMedCrossRefGoogle Scholar
  5. 5.
    Adelsberger H, Quasthoff S, Grosskreutz J, Lepier A, Eckel F, Lersch C (2000) The chemotherapeutic oxaliplatin alters voltage-gated Na+ channel kinetics on rat sensory neurons. Eur J Pharmacol 406:25–32Google Scholar
  6. 6.
    Grolleau F, Gamelin L, Boisdron-Celle M, Lapied B, Pelhate M, Gamelin E (2001) A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels. J Neurophysiol 85:2293–2297PubMedGoogle Scholar
  7. 7.
    Webster RG, Brain KL, Wilson RH, Grem JL, Vincent A (2005) Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage-gated sodium channels. Br J Pharmacol 146:1027–1039PubMedCrossRefGoogle Scholar
  8. 8.
    Benoit E, Brienza S, Dubois JM (2006) Oxaliplatin, an anticancer agent that affects both Na+ and K+ channels in frog peripheral myelinated axons. Gen Physiol Biophys 25:263–276PubMedGoogle Scholar
  9. 9.
    Wu S-N, Chen B-S, Wu Y-H, Peng H, Chen L-T (2009) The mechanism of the actions of oxaliplatin on ion currents and action potentials in differentiated NG108–15 neuronal cells. Neurotoxicol 30:677–685CrossRefGoogle Scholar
  10. 10.
    Broomand A, Jerremalm E, Yachnin J, Ehrsson H, Elinder F (2009) Oxaliplatin neurotoxicity—no general ion channel surface-charge effect. J Negat Results Biomed 8:2PubMedCrossRefGoogle Scholar
  11. 11.
    Kagiava A, Tsingotjidou A, Emmanouilides C, Theophilidis G (2008) The effects of oxaliplatin, an anticancer drug, on potassium channels of the peripheral myelinated nerve fibres of the adult rat. Neurotoxicol 29:1100–1106CrossRefGoogle Scholar
  12. 12.
    Schwarz JR, Reid G, Bostock H (1995) Action potentials and membrane currents in the human node of Ranvier. Pflugers Archiv 430:283–292PubMedCrossRefGoogle Scholar
  13. 13.
    Jacobsen D, Herson PS, Neelands TR, Maylie J, Adelman JP (2002) SK channels are necessary but not sufficient for denervation-induced hyperexcitability. Muscle Nerve 26:817–822CrossRefGoogle Scholar
  14. 14.
    Sittl R, Carr RW, Fleckenstein J, Grafe P (2010) Enhancement of axonal potassium conductance reduces nerve hyperexcitability in an in vitro model of oxaliplatin-induced acute neuropathy. Neurotoxicol. doi: 10.1016/j.neuro.2010.07.006

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Susanna B. Park
    • 1
  • Cindy S-Y. Lin
    • 2
  • Arun V. Krishnan
    • 2
  • Matthew C. Kiernan
    • 1
  1. 1.Neuroscience Research Australia and Prince of Wales Clinical SchoolUniversity of New South WalesRandwick SydneyAustralia
  2. 2.School of Medical SciencesUniversity of New South WalesSydneyAustralia

Personalised recommendations