Cancer Chemotherapy and Pharmacology

, Volume 66, Issue 2, pp 265–267 | Cite as

Cisplatin administration following carboplatin desensitization failure in primary peritoneal cancer: a brief report

  • Daniel P. Greene
  • James Stuart Ferriss
  • Amir A. Jazaeri
Original Article

Abstract

Purpose

Platinum-based therapy is the cornerstone of ovarian cancer treatment. Development of platinum hypersensitivity can limit therapeutic options. In this brief report, we present case of successful cisplatin administration following two unsuccessful carboplatin desensitization attempts, and without the need for pre-treatment steroids.

Methods

Retrospective chart review was performed.

Results

One case of recurrent primary peritoneal carcinoma previously treated with a carboplatin-based regimen, developed a platinum hypersensitivity. Two attempts at carboplatin desensitization were unsuccessful. Cisplatin was substituted and the patient achieved a complete response to therapy without further hypersensitivity.

Conclusions

Platinum-based therapies are vital to the treatment of primary peritoneal and ovarian carcinoma. Protocols that successfully incorporate platinum agents, despite a platinum hypersensitivity, are clinically relevant.

Keywords

Platinum hypersensitivity Peritoneal carcinoma Platinum desensitization failure Cisplatin 

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Daniel P. Greene
    • 1
  • James Stuart Ferriss
    • 2
  • Amir A. Jazaeri
    • 2
  1. 1.University of Virginia School of MedicineCharlottesvilleVAUSA
  2. 2.Thornton Gynecologic Oncology Service, Department of Obstetrics and GynecologyUniversity of Virginia Health SystemCharlottesvilleUSA

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