Cancer Chemotherapy and Pharmacology

, Volume 64, Issue 4, pp 647–655 | Cite as

Temozolomide in malignant gliomas: current use and future targets

  • J. Lee Villano
  • Tara E. Seery
  • Linda R. Bressler
Mini Review

Abstract

Temozolomide (TMZ) is an oral alkylating agent that is regarded as a tolerable and effective drug. When combined with radiotherapy in patients with newly diagnosed glioblastoma, survival is significantly prolonged. This finding has led to widespread use of TMZ for patients with this disease. We summarize developing concerns regarding the use of TMZ, imaging of malignant gliomas, and the pharmacology of TMZ—mechanism of action, scheduling and strategies for overcoming resistance.

Keywords

Temozolomide Brain tumor Alkylating chemotherapy Malignant glioma Glioblastoma Tumor resistance 

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • J. Lee Villano
    • 1
  • Tara E. Seery
    • 1
  • Linda R. Bressler
    • 2
  1. 1.Section of Hematology/Oncology, Department of MedicineUniversity of Illinois at ChicagoChicagoUSA
  2. 2.Department of Pharmacy PracticeUniversity of Illinois at ChicagoChicagoUSA

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