Cancer Chemotherapy and Pharmacology

, Volume 64, Issue 2, pp 431–432

Anthocyanins-based drugs for colon cancer treatment: the nutritionist’s point of view

  • Fabio Galvano
  • Federico Salamone
  • Anna Nicolosi
  • Paola Vitaglione
Letter to the Editor


  1. 1.
    Thomasset S, Teller N, Cai H, Marko D, Berry DP, Steward WP, Gescher JA (2009) Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs? Cancer Chemother Pharmacol 64:201–211Google Scholar
  2. 2.
    Vitaglione P, Donnarumma G, Napolitano A, Galvano F, Gallo A, Scalfi L, Fogliano V (2007) Protocatechuic acid is the major human metabolite of cyanidin-glucoside. J Nutr 137:2043–2048PubMedGoogle Scholar
  3. 3.
    Tsuda T, Horio F, Osawa T (1999) Absorption and metabolism of cyanidin 3-o-beta-d-glucoside in rats. FEBS Lett 449:179–182PubMedCrossRefGoogle Scholar
  4. 4.
    Wu X, Pittman HE, Hager T, Hager A, Howard L, RL Prior (2009) Phenolic acids in black raspberry and in the gastrointestinal tract of pigs following ingestion of black raspberry. Mol Nutr Food Res 53. doi:10.1002/mnfr.200800231
  5. 5.
    McGhie TK, Walton MC (2007) The bioavailability and absorption of anthocyanins: towards a better understanding. Mol Nutr Food Res 51:702–713PubMedCrossRefGoogle Scholar
  6. 6.
    Galvano F, Vitaglione P, Di Giacomo C, Gazzolo D, Li Volti G, Vanella L, La Fauci L, Fogliano V (2008) Protocatechuic acid: the missing human cyanidins’ metabolite. Mol Nutr Food Res 52:386–387PubMedCrossRefGoogle Scholar
  7. 7.
    Tanaka T, Kojima T, Suzui M, Mori H (1993) Chemoprevention of colon carcinogenesis by the natural product of a simple phenolic compound protocatechuic acid: suppressing effects on tumor development and biomarkers expression of colon tumorigenesis. Cancer Res 53:3908–3913PubMedGoogle Scholar
  8. 8.
    Lin HH, Chen JH, Huang CC, Wang CJ (2007) Apoptotic effect of 3, 4-dihydroxybenzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation. Int J Cancer 120:2306–2316PubMedCrossRefGoogle Scholar
  9. 9.
    Zheng Q, Hirose Y, Yoshimi N, Murakami A, Koshimizu K, Ohigashi H, Sakata K, Matsumoto Y, Sayama Y, Mori H (2002) Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells. J Cancer Res Clin Oncol 128:539–546PubMedCrossRefGoogle Scholar
  10. 10.
    Mori H, Tanaka T, Sugie S, Yoshimi N, Kawamori T, Hirose Y, Ohnishi M (1997) Chemoprevention by naturally occurring and synthetic agents in oral, liver, and large bowel carcinogenesis. J Cell Biochem S27:35–41CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Fabio Galvano
    • 1
  • Federico Salamone
    • 2
  • Anna Nicolosi
    • 1
  • Paola Vitaglione
    • 3
  1. 1.Department of Biological Chemistry, Medical Chemistry and Molecular BiologyUniversity of CataniaCataniaItaly
  2. 2.Department of Internal MedicineUniversity of CataniaCataniaItaly
  3. 3.Department of Food Science“Federico II” University of NaplesNaplesItaly

Personalised recommendations